Edit Target: 103
Vitamin like substance. Found in cereals, nuts and legumes.
Inositol hexaphosphate (IP6) is a dietary component that constitutes approximately 1 to 5% of the weight of most cereals, nuts, oil seeds, legumes, and grains [1, 2]. In particular, approximately 9.5 to 14.5% of the weight of rice bran is composed of IP6.
• Antioxidant Activity
– IP6 can chelate metal ions and scavenge free radicals, thereby reducing oxidative stress and preventing DNA damage that could initiate or promote cancer.
• Modulation of Signal Transduction Pathways
– IP6 influences key pathways such as PI3K/Akt and MAPK, which are involved in cell survival, growth, and proliferation. Its modulation can lead to reduced cell proliferation and enhanced apoptotic signaling.
• Induction of Apoptosis
– By activating pro-apoptotic factors and suppressing anti-apoptotic proteins, IP6 promotes programmed cell death in cancer cells.
• Cell Cycle Arrest
– IP6 has been shown to interfere with cell cycle progression, particularly by regulating cyclin-dependent kinases. This arrest can prevent the rapid and uncontrolled division of cancer cells.
• Promotion of Cell Differentiation
– IP6 may encourage malignant cells to differentiate into more normal cell types, which typically have reduced proliferative abilities and lower tumorigenic potential.
• Inhibition of Angiogenesis
– By disrupting the signals needed for new blood vessel formation, IP6 can limit the tumor’s blood supply, thereby restricting tumor growth and metastasis.
• Immune Modulation
– Some studies suggest that IP6 may enhance the immune response against tumors, contributing to its overall anti-cancer activity.