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pid
Abbr	MSM
Name	Methylsulfonylmethane
Type
Features

Natural Product : MSM, Methylsulfonylmethane

MSM (Methylsulfonylmethane) is a naturally occurring organosulfur compound often used as a dietary supplement for its anti-inflammatory and antioxidant effects. While most well-known for joint health.
-MSM is actually a metabolite of DMSO (dimethyl sulfoxide)

-Generally Recognized as Safe     Possible Interactions: aspirin, warfarin, NSAIDS

-Supplement dosage: 500mg 2-3times/day


-Anti-inflammatory: ↓NF-κB, ↓COX-2 and iNOS
-↓STAT3
-↓Cyclin D1 and CDK4, halting cell cycle progression.
-↓MMP-2, MMP-9, VEGF limiting invasion.

For Alzheimer's (AD):
-Anti-inflammatory: ↓TNF-α, IL-1β, IL-6 
-↓ROS, ↑GSH, ↓NO
-may reduce Aβ plaque burden and tau hyperphosphorylation indirectly
-improves memory in rodents

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