Edit Target: 127
Myricetin is a naturally occurring flavonoid that has been the subject of extensive preclinical studies for its potential anticancer properties.
Pathways:
-Inhibit the PI3K/Akt signaling pathway, which is often hyperactive in many cancers
-MAPK/ERK Pathway
-Inhibit NF‑κB activation
-Activate or enhance p53 signaling, thereby contributing to its anticancer effects
-AK/STAT Signaling
-May inhibit angiogenesis (VEGF)
-Suppress the processes involved in metastasis, such as matrix metalloproteinase (MMP) activity
-Can exert antioxidant effects; however, in cancer cells, it sometimes induces oxidative stress beyond a threshold, contributing to apoptotic cell death.
-Inhibitory effects on mammalian TrxRs (thioredoxin reductase)