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Red sage, redroot sage, Chinese sage or danshen.
Salvianolic Acid A (SAA) is predominantly isolated from Salvia miltiorrhiza, commonly known as Danshen.
Tanshinone IIA is the main effective component of Salvia miltiorrhiza known as 'Danshen'
Salvianolic Acid A, primarily derived from Salvia miltiorrhiza (Danshen), shows promise in cancer research due to its ability to inhibit cell proliferation, induce apoptosis, reduce angiogenesis, and impact multiple signaling pathways involved in tumor progression.
Salvianolic Acid A may impact several intracellular signaling pathways involved in cancer progression:
NF-κB Pathway: SAA might inhibit the NF-κB pathway, reducing inflammation and cell proliferation signals.
MAPK Pathways (ERK, JNK, p38): By modulating these pathways, SAA can influence cell survival, differentiation, and apoptosis.
PI3K/Akt Pathway: Inhibition of this pathway is another mechanism through which SAA can reduce cancer cell survival and proliferation.
Oxidative Stress Reduction: SAA’s antioxidant properties may help in reducing oxidative stress, which is implicated in cancer progression and chemoresistance.
Synergistic Effects with Conventional Therapies:
Preliminary studies suggest that Salvianolic Acid A might enhance the effectiveness of various chemotherapeutic agents.
Some studies have observed anti-proliferative effects at concentrations around 10–50 µM.
rodent models have been reported in the range of 10–100 mg/kg