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pH-alkalization therapy is a term used to describe strategies aimed at altering the pH (or acidity/alkalinity) of the tumor microenvironment in an effort to inhibit cancer growth and spread.
-Normal tissues have a higher extracellular pH than intracellular pH, in cancer is exactly the opposite (inversion of the pH gradient).
-Acidic Microenvironment: Many tumors exhibit an acidic microenvironment. This is largely due to the high rate of glycolysis (often referred to as the Warburg effect), even in the presence of oxygen, leading to lactate production. Acidification is thought to promote invasion, metastasis, and resistance to certain chemotherapies.
-The basic premise behind pH-alkalization therapy is that by increasing the pH (making the environment less acidic), one might impair cancer cells’ adaptive advantage, reduce their proliferative and invasive capabilities, and perhaps render them more susceptible to standard treatments.
-Various approaches have been proposed to achieve a more alkaline microenvironment, such as dietary modifications (e.g., an "alkaline diet"), supplements (like bicarbonate), or drugs designed to interfere with proton pumps or transporters on cancer cells.
-Most experts view pH-alkalization strategies as potentially complementary to conventional therapies (e.g., chemotherapy, radiotherapy, immunotherapy), rather than as a standalone cure for cancer.
Natural Products with possible effect:
Fruits
-Lemons and Limes:acidic in their natural state, often considered alkalizing after digestion
-Watermelon: High water content and alkaline minerals.
-Berries: Blueberries, raspberries, and strawberries antioxidants and have alkalizing minerals.
-Avocado: Provides healthy fats and may have an alkalizing effect.
Vegetables
-Leafy Greens: Spinach, kale, swiss chard, and collard greens (chlorophyll, to help reduce acidity.)
-Broccoli and Cauliflower: Cruciferous vegetables with a good mineral profile to support alkalinity.
-Cucumber: High water content and mild alkalizing properties.
-Celery: Often recommended for its hydrating and alkalizing effect.
Nuts & Seeds
-Almonds: Considered one of the more alkaline nuts.
-Flaxseeds and Chia Seeds: Rich in omega-3s and other minerals that may contribute positively.
-Legumes & Grains Quinoa: lower acid load compared to some other grains.
-Lentils:Provide protein and fiber while being relatively alkaline in nature.
Others
-Herbal Teas: Teas made from herbs like ginger or chamomile may support a balanced internal environment.
-Coconut Water: Rich in electrolytes and naturally alkaline.
-Baking Soda (Sodium Bicarbonate):
-Green Juices: Juices or smoothies made predominantly from leafy greens and vegetables can help maintain a mineral balance that leans toward alkalinity.