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Wortmannin is a naturally occurring compound that is known for its inhibitory effects on certain enzymes, particularly phosphatidylinositol 3-kinase (PI3K). It is a fungal metabolite that was first isolated from the fungus Penicillium wortmanni.
Widely used in research as a tool to study the PI3K signaling pathway.
-known as AKT inhibitor
Wortmannin is a potent, naturally derived compound best known for its role as an inhibitor of phosphoinositide 3-kinases (PI3Ks). Unlike vitamins such as vitamin D or vitamin K2, wortmannin is not used as a nutritional supplement or therapeutic agent in the typical clinical setting.
- In cell culture studies, wortmannin is commonly used at concentrations in the low nanomolar range (e.g., 10–100 nM) to inhibit PI3K activity.
- In animal models, the dosing regimen can vary widely depending on the species, route of administration, and study design. Typical experimental doses may range from 0.1 to 1.0 mg/kg, but these studies are primarily investigative and not directed toward therapeutic dosing in humans.