Edit: by Product Abbr , 2DG, 2-DeoxyGlucose3BP, 3-bromopyruvate5-ALA, 5-Aminolevulinic acid5-FU, 5-fluorouracil5-HTP, 5-Hydroxytryptophanacet, acetaminophenacetaz, acetazolamideACNs, AnthocyaninsAco, Acoschimperoside P, 2’-acetateAdag, AdagrasibAG, ArctigeninAjoene, Ajoene (compound of Garlic)Akk, AkkermansiaAL, Allicin (mainly Garlic)ALA, Alpha-Lipoic-AcidaLinA, alpha Linolenic acidalmon, almonertinibAMQ, AmodiaquineAnamu, dibenzyl trisulphide(DTS) from AnamuAnd, AndrographisantiOx, Anti-oxidantsAP, Ascorbyl PalmitateApi, Apigenin (mainly Parsley)ART/DHA, ArtemisininAS, AstragalusASA, Aspirin -acetylsalicylic acidAsh, AshwagandhaATAGJ, Ai-Tong-An-Gao-JiATO, Arsenic trioxideATV, AtorvastatinAur, AuranofinAV, Aloe veraB-Gluc, beta-glucansBa, BaicaleinBA, BaicalinBA, ButyrateBaP, benzo(a)pyreneBBM, BerbamineBBR, BerberineBCA, Biochanin Abemp, bempedoic acidBetA, Betulinic acidbetaCar, beta-caroteneBEV, Bevacizumab (brand Avastin)BF, BufalinBical, BicalutamideBif, BifidobacteriumBJ, Brucea javanicaBML, BromelainBor, Boronborn, borneolBos, Boswellia (frankincense)BP, Black phosphorusBrut, BruteridinBTZ, BortezomibCA, Carnosic acidCA, Caffeic acidCaff, CaffeineCalc, CalciumCAP, Capsaicincapec, capecitabineCAR, Carvacrolcarbop, carboplatinCatechins, CatechinsCats, Cat’s ClawCBC, CannabichromeneCBC/D, Cynanbungeigenin C (CBC) and D (CBD)CBD, CannabidiolCBDA, cannabidiolic acidCDT, chemodynamic therapyCEL, CelecoxibCela, CelastrolCET, cetuximabCGA, Chlorogenic acidChemo, ChemotherapyChit, chitosanCHL, ChlorophyllinCHOC, ChocolateCHr, ChrysinCin, CinnamonCisplatin, CisplatinCitrate, Citric AcidCP, CyclopamineCPT, CamptothecinCRMs, Calorie Restriction MimeticsCroc, CrocetinCu, Copper and Cu NanoParticlexCuc, CucurbitacinCUR, CurcuminCUSP9, CUSP9Dand, Dandelion RootDAP, Dichloroacetophenone(2,2-)DAS, DasatinibDCA, DichloroacetateDeg, DeguelinDHA, Docosahexaenoic AcidDHCA, Dihydrocaffeic AcidDicl, DiclofenacdietF, diet Fermented FoodsdietFMD, diet FMD Fasting Mimicking DietdietKeto, diet KetogenicdietMet, diet Methionine-Restricted DietdietP, diet Plant basedDipy, DipyridamoleDL, D-limonenedocx, DocetaxeldoxoR, doxorubicinDSMO, Dimethyl SulfoxideEA, Ellagic acidEch, EchinaceaEDM, EvodiamineEDTA, ethylene diamine tetraacetic acidEGCG, EGCG (Epigallocatechin Gallate)EMD, EmodinEP, Electrical PulsesEPA, eicosapentaenoic acidEPI, epirubicinerastin, erastinEst, EstrogenEx, ExerciseF, FucoidanFA, Folic AcidFA, Ferulic acidFe, IronFenb, FenbendazoleFer, ferumoxytolFIS, FisetinFlav, flavonoidsForm, FormononetinGA, Gallic acidGallo, GalloflavinGamB, Gambogic AcidGAR, GarcinolGB, Ginkgo bilobaGB, gefitinib, erlotinibGE, GermaniumGe, Grapeseed extractGEM, Gemcitabine (Gemzar)GEN, GenisteinGer, GermacranolideGI, Ginger/6-Shogaol/GingerolGins, GinsengGlaB, Glabrescione BGluc, GlucoseGlucDep, glucose deprivationGoldNP, Gold NanoParticlesGos, GossypolGra, GraviolaGSL, Siegesbeckia glabrescensH2, Hydrogen GasHCA, HydroxyCitric AcidHCAs, Hydroxycinnamic-acidHCO3, BicarbonateHCQ, hydroxychloroquineHibSad, Hibiscus sabdariffaHne, Helleborus niger extracts – Christmas RoseHNK, HonokiolHOO, High-Ozonide OilHops, Hops (Humulus lupulus)HP, HyperosideHPT, HyperthermiaHRT, Hormone replacement therapyHTyr, HydroxytyrosolI3C, Indole-3-carbinolIMA, imatinibimmuno, immunotherapyInA, Inoscavin AIns, Inositoliod, iodineIP, Inulin PrebioticIP6, IP6 (Inosital 1,2,3,4,5,6-hexakisphosphate)isoFl, isoflavonesitraC, itraconazoleIVM, IvermectinJG, JugloneKaempF, KaempferolL-A, L-AlinineL-Orn, L-ornithineLA, LactobacillusLae, Laetrile B17 Amygdalinlamb, lambertianic acidLap, LapatinibLapC, LapacholLas, LasiodinLDN, low dose naltrexoneLE, LicoriceLEC, LecithinLF, Lactoferrinlign, lignansLip, Lipoic acidlpi, ipilimumabLT, LuteolinLyco, LycopeneM-Blu, Methylene blueMAG, MagnololMatr, MatrineMCP, Modified Citrus PectinMCT, MCToilmeben, mebendazoleMeJa, Methyl JasmonateMel, MelitidinMEL, MelatoninMeSA, methylseleninic acidMET, MetforminmetroC, metronomic chemoMF, Magnetic FieldsMFrot, Magnetic Field RotatingMg, MagnesiumMGO, MethylglyoxalMNPs, magnetic nanoparticlesMoringa, Moringa oleiferaMS-275, entinostatMSM, MethylsulfonylmethaneMT, MistletoeMTX, methotrexateMushCha, Mushroom ChagamushLions, Mushroom Lion’s ManeMushMait, Mushroom MaitakeMushPL, Mushroom Phellinus. linteusMushReishi, Mushroom ReishiMushShi, Mushroom Shiitake, AHCCmushTT, mushroom Turkey TailMyr, MyricetinMyrrh, MyrrhNAD, nicotinamide adenine dinucleotideNarG, NaringinNCL, Niclosamide (Niclocide)Nimb, NimbolideNIV, nivolumabNos, NoscapineNRF, nelfinavir/ViraceptOA, Oroxylin-AOA, Oroxylin AOAA, oxaloacetateOctr, octreotideOLST, OrlistatOsi, OsimertinibOXA, OxaliplatinOxy, Oxygen, HyperbaricP, PeppermintPA, Pachymic acidPACs, ProanthocyanidinsPacT, PaclitaxelPap, papainPart, ParthenolidePawPaw, Paw PawPB, PhenylbutyratePBG, Propolis -bee gluePDT, Photodynamic TherapyPem, pembrolizumabPer, PerillaPFB, Physalin F & BPG, Propyl gallatepH-AT, pH-Alkalization TherapyPhen, PXD, phenoxodiolPI, PiperinePIT, PitavastatinPL, PiperlonguminePlum, PlumbaginProBio, probioticsPS, PterostilbenePurp, PurpuroneQC, QuercetinRad, Radiotherapy/RadiationRalox, raloxifenRAPA, RapamycinRES, ResveratrolRetA, Retinoic AcidRF, Radio FrequencyRF, EMFRosA, Rosmarinic acidRSL3, Ras-selective lethal 3RSQ, ResiquimodRT, RutinSAHA, VorinostatSal, salinomycinSANG, SanguinarineSB, Saccharomyces boulardiiSco, ScoulerineSDT, SonoDynamic Therapy UltraSoundSe, SeleniumSel, SeleniteSelenate, SelenateSeMet, selenomethioninesericin, sericinSFN, Sulforaphane (mainly Broccoli)SIL, Silymarin (Milk Thistle) silibininSIM, SimvastatinSK, ShikoninSM, Salvia miltiorrhizaSNP, Silver-NanoParticlesSNT, sunitinibSqu, SqualeneSRF, Sorafenib (brand name Nexavar)SS, Saikosaponin B1 and Dstatins, statinsSTF, Short Term FastingSuD, Sutherlandioside DSulfas, SulfasalazineTACE, Transarterial ChemoembolizationTam, tamoxifenTau, TaurineTb, TheobromineTC, Tinospora CordifoliaTF, TheaflavinTFdiG, Aflavin-3,3′-digallateTiO2, Titanium DioxideTMZ, temozolomideTomatine, TomatineTQ, ThymoquinoneTras, TrastuzumabTrip, triptolideTSA, Trichostatin ATTT, Tumor Treating FieldsTu, TulsiTV, Thymol-Thymus vulgarisUA, Ursolic acidUkrain, Ukrainurea, ureaVem, verapamilVitB1/Thiamine, VitB1/ThiamineVitB12, Vitamin B12VitC, Vitamin C (Ascorbic Acid)VitD3, Vitamin D3VitE, Vitamin EVitK2, Vitamin K2VitK3, VitK3,menadioneWBV, Whole Body VibrationWog, WogoninWor, Woreninewortm, wortmanninXyl, XylitolZ, ZincZeo, ZeoliteZO, Zinc Oxideβ‐Ele, β‐Elemeneγ-Toc, γ-Tocotrienol

    Edit: by Product Name , 2DG, 2-DeoxyGlucose3BP, 3-bromopyruvate5-ALA, 5-Aminolevulinic acid5-FU, 5-fluorouracil5-HTP, 5-Hydroxytryptophanacet, acetaminophenacetaz, acetazolamideAco, Acoschimperoside P, 2’-acetateAdag, AdagrasibTFdiG, Aflavin-3,3′-digallateATAGJ, Ai-Tong-An-Gao-JiAjoene, Ajoene (compound of Garlic)Akk, AkkermansiaAL, Allicin (mainly Garlic)almon, almonertinibAV, Aloe veraaLinA, alpha Linolenic acidALA, Alpha-Lipoic-AcidAMQ, AmodiaquineAnd, AndrographisACNs, AnthocyaninsantiOx, Anti-oxidantsApi, Apigenin (mainly Parsley)AG, ArctigeninATO, Arsenic trioxideART/DHA, ArtemisininAP, Ascorbyl PalmitateAsh, AshwagandhaASA, Aspirin -acetylsalicylic acidAS, AstragalusATV, AtorvastatinAur, AuranofinBa, BaicaleinBA, Baicalinbemp, bempedoic acidBaP, benzo(a)pyreneBBM, BerbamineBBR, BerberinebetaCar, beta-caroteneB-Gluc, beta-glucansBetA, Betulinic acidBEV, Bevacizumab (brand Avastin)Bical, BicalutamideHCO3, BicarbonateBif, BifidobacteriumBCA, Biochanin ABP, Black phosphorusborn, borneolBor, BoronBTZ, BortezomibBos, Boswellia (frankincense)BML, BromelainBJ, Brucea javanicaBrut, BruteridinBF, BufalinBA, ButyrateCA, Caffeic acidCaff, CaffeineCalc, CalciumCRMs, Calorie Restriction MimeticsCPT, CamptothecinCBC, CannabichromeneCBD, CannabidiolCBDA, cannabidiolic acidcapec, capecitabineCAP, Capsaicincarbop, carboplatinCA, Carnosic acidCAR, CarvacrolCats, Cat’s ClawCatechins, CatechinsCela, CelastrolCEL, CelecoxibCET, cetuximabCDT, chemodynamic therapyChemo, ChemotherapyChit, chitosanCGA, Chlorogenic acidCHL, ChlorophyllinCHOC, ChocolateCHr, ChrysinCin, CinnamonCisplatin, CisplatinCitrate, Citric AcidCu, Copper and Cu NanoParticlexCroc, CrocetinCuc, CucurbitacinCUR, CurcuminCUSP9, CUSP9CP, CyclopamineCBC/D, Cynanbungeigenin C (CBC) and D (CBD)DL, D-limoneneDand, Dandelion RootDAS, DasatinibDeg, DeguelinAnamu, dibenzyl trisulphide(DTS) from AnamuDCA, DichloroacetateDAP, Dichloroacetophenone(2,2-)Dicl, DiclofenacdietF, diet Fermented FoodsdietFMD, diet FMD Fasting Mimicking DietdietKeto, diet KetogenicdietMet, diet Methionine-Restricted DietdietP, diet Plant basedDHCA, Dihydrocaffeic AcidDSMO, Dimethyl SulfoxideDipy, Dipyridamoledocx, DocetaxelDHA, Docosahexaenoic AciddoxoR, doxorubicinEch, EchinaceaEGCG, EGCG (Epigallocatechin Gallate)EPA, eicosapentaenoic acidEP, Electrical PulsesEA, Ellagic acidRF, EMFEMD, EmodinMS-275, entinostatEPI, epirubicinerastin, erastinEst, EstrogenEDTA, ethylene diamine tetraacetic acidEDM, EvodiamineEx, ExerciseFenb, FenbendazoleFA, Ferulic acidFer, ferumoxytolFIS, FisetinFlav, flavonoidsFA, Folic AcidForm, FormononetinF, FucoidanGA, Gallic acidGallo, GalloflavinGamB, Gambogic AcidGAR, GarcinolGB, gefitinib, erlotinibGEM, Gemcitabine (Gemzar)GEN, GenisteinGer, GermacranolideGE, GermaniumGI, Ginger/6-Shogaol/GingerolGB, Ginkgo bilobaGins, GinsengGlaB, Glabrescione BGluc, GlucoseGlucDep, glucose deprivationGoldNP, Gold NanoParticlesGos, GossypolGe, Grapeseed extractGra, GraviolaHne, Helleborus niger extracts – Christmas RoseHibSad, Hibiscus sabdariffaHOO, High-Ozonide OilHNK, HonokiolHops, Hops (Humulus lupulus)HRT, Hormone replacement therapyH2, Hydrogen GasHCQ, hydroxychloroquineHCAs, Hydroxycinnamic-acidHCA, HydroxyCitric AcidHTyr, HydroxytyrosolHP, HyperosideHPT, HyperthermiaIMA, imatinibimmuno, immunotherapyI3C, Indole-3-carbinolInA, Inoscavin AIns, InositolIP, Inulin Prebioticiod, iodineIP6, IP6 (Inosital 1,2,3,4,5,6-hexakisphosphate)lpi, ipilimumabFe, IronisoFl, isoflavonesitraC, itraconazoleIVM, IvermectinJG, JugloneKaempF, KaempferolL-A, L-AlinineL-Orn, L-ornithineLA, LactobacillusLF, LactoferrinLae, Laetrile B17 Amygdalinlamb, lambertianic acidLapC, LapacholLap, LapatinibLas, LasiodinLEC, LecithinLE, Licoricelign, lignansLip, Lipoic acidLDN, low dose naltrexoneLT, LuteolinLyco, LycopeneMg, MagnesiumMFrot, Magnetic Field RotatingMF, Magnetic FieldsMNPs, magnetic nanoparticlesMAG, MagnololMatr, MatrineMCT, MCToilmeben, mebendazoleMEL, MelatoninMel, MelitidinMET, MetforminMTX, methotrexateMeJa, Methyl JasmonateM-Blu, Methylene blueMGO, MethylglyoxalMeSA, methylseleninic acidMSM, MethylsulfonylmethanemetroC, metronomic chemoMT, MistletoeMCP, Modified Citrus PectinMoringa, Moringa oleiferaMushCha, Mushroom ChagamushLions, Mushroom Lion’s ManeMushMait, Mushroom MaitakeMushPL, Mushroom Phellinus. linteusMushReishi, Mushroom ReishiMushShi, Mushroom Shiitake, AHCCmushTT, mushroom Turkey TailMyr, MyricetinMyrrh, MyrrhNarG, NaringinNRF, nelfinavir/ViraceptNCL, Niclosamide (Niclocide)NAD, nicotinamide adenine dinucleotideNimb, NimbolideNIV, nivolumabNos, NoscapineOctr, octreotideOLST, OrlistatOA, Oroxylin AOA, Oroxylin-AOsi, OsimertinibOXA, OxaliplatinOAA, oxaloacetateOxy, Oxygen, HyperbaricPA, Pachymic acidPacT, PaclitaxelPap, papainPart, ParthenolidePawPaw, Paw PawPem, pembrolizumabP, PeppermintPer, PerillapH-AT, pH-Alkalization TherapyPB, PhenylbutyratePDT, Photodynamic TherapyPFB, Physalin F & BPI, PiperinePL, PiperlonguminePIT, PitavastatinPlum, PlumbaginPACs, ProanthocyanidinsProBio, probioticsPBG, Propolis -bee gluePG, Propyl gallatePS, PterostilbenePurp, PurpuronePhen, PXD, phenoxodiolQC, QuercetinRF, Radio FrequencyRad, Radiotherapy/RadiationRalox, raloxifenRAPA, RapamycinRSL3, Ras-selective lethal 3RSQ, ResiquimodRES, ResveratrolRetA, Retinoic AcidRosA, Rosmarinic acidRT, RutinSB, Saccharomyces boulardiiSS, Saikosaponin B1 and DSal, salinomycinSM, Salvia miltiorrhizaSANG, SanguinarineSco, ScoulerineSelenate, SelenateSel, SeleniteSe, SeleniumSeMet, selenomethioninesericin, sericinSK, ShikoninSTF, Short Term FastingGSL, Siegesbeckia glabrescensSNP, Silver-NanoParticlesSIL, Silymarin (Milk Thistle) silibininSIM, SimvastatinSDT, SonoDynamic Therapy UltraSoundSRF, Sorafenib (brand name Nexavar)Squ, Squalenestatins, statinsSulfas, SulfasalazineSFN, Sulforaphane (mainly Broccoli)SNT, sunitinibSuD, Sutherlandioside DTam, tamoxifenTau, TaurineTMZ, temozolomideTF, TheaflavinTb, TheobromineTV, Thymol-Thymus vulgarisTQ, ThymoquinoneTC, Tinospora CordifoliaTiO2, Titanium DioxideTomatine, TomatineTACE, Transarterial ChemoembolizationTras, TrastuzumabTSA, Trichostatin ATrip, triptolideTu, TulsiTTT, Tumor Treating FieldsUkrain, Ukrainurea, ureaUA, Ursolic acidVem, verapamilVitB12, Vitamin B12VitC, Vitamin C (Ascorbic Acid)VitD3, Vitamin D3VitE, Vitamin EVitK2, Vitamin K2VitB1/Thiamine, VitB1/ThiamineVitK3, VitK3,menadioneSAHA, VorinostatWBV, Whole Body VibrationWog, WogoninWor, Woreninewortm, wortmanninXyl, XylitolZeo, ZeoliteZ, ZincZO, Zinc Oxideβ‐Ele, β‐Elemeneγ-Toc, γ-Tocotrienol

Edit Target: 223

pid
Abbr	MTX
Name	methotrexate
Type	NA, NANP, Natural ProductD, DrugRD, Repurposed DrugT, TherapyIM, Immunomodulatory antibodiesPC, Protocol
Features

Methotrexate is a chemotherapy medication that has been used to treat various types of cancer.
Methotrexate works by:
Inhibiting dihydrofolate reductase (DHFR): Methotrexate binds to DHFR, an enzyme that is necessary for the production of tetrahydrofolate, a co-factor for DNA synthesis.
Interfering with DNA synthesis: By inhibiting DHFR, methotrexate prevents the production of tetrahydrofolate, which is necessary for DNA synthesis.
Inducing apoptosis: Methotrexate can induce apoptosis (programmed cell death) in cancer cells.




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