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Mushroom Shiitake, Active hexose correlated compound
Extracted from Basidiomycete mushrooms (eg, shiitake [Lentinula edodes]) that is purported to improve immune function.
Summary:
- Can significantly inhibit carcinogenesis and improve anti-tumor effects, thus increasing the effectiveness of cancer immunotherapy.
- Enhanced abundance of Akkermansia in the intestine of those who responded positively to the ICI(immune checkpoint inhibitors).
-Eat fermented foods then fibre to maintain them. Fruits and vegs for fibre Chicory
root for fibre (inulin which is main prebiotic)
AHCC is mainly derived from the mycelium of Shiitake mushrooms.
• It is rich in polysaccharides that are believed to enhance immune function.
• The compound may influence various pathways in cancer, including boosting NK cell activity, modulating cytokine production, influencing the NF-kB inflammatory pathway, and reducing oxidative stress.
Pathways:
-Stimulate cytokine production (e.g., interleukins, tumor necrosis factor) and enhance the function of macrophages and dendritic cells. https://pubmed.ncbi.nlm.nih.gov/28727820/