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Bruteridin is a lesser-known phytochemical that has been isolated from certain plant sources. Like other natural compounds with polyphenolic characteristics, bruteridin is of interest because of its potential antioxidant and anti-inflammatory activities. However, due to the limited body of research, its specific role as an anticancer agent remains largely underexplored.
Typically associated with natural cardenolide mixtures from specific cardenolide-producing plants (e.g., species in the Digitalis or Adonis genera) and possibly from amphibian secretions.
-Antioxidant Activity
-Anti-inflammatory Effects
-Changes in histone acetylation status and chromatin remodeling can lead to altered gene expression profiles that favor tumor suppression.
-Na+/K+-ATPase Inhibition
-interfere with the PI3K/Akt/mTOR signaling cascade
-linked to the generation of ROS within cells
-Cell Cycle Arrest
-Inhibition of NF-κB Signaling
-alter the MAPK/ERK signaling cascade