Edit Target: 279
Purpurone is a natural product. Many reports indicate that it belongs to a family of naphthoquinone derivatives.
Pathways:
Induction of Apoptosis (Intrinsic/Mitochondrial Pathway):
– affecting MMP, leading to the release of cytochrome c and activation of downstream caspases.
Inhibition of NF-κB Signaling:
Cell Cycle Arrest: (often at the G2/M phase).
Induction of Oxidative Stress (ROS Generation):
Anti-Angiogenic Effects: inhibiting angiogenesis
ACLY inhibitor: IC50 = 7 uM