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Noscapine is a natural product. It is an isoquinoline alkaloid derived from the opium poppy (Papaver somniferum), although unlike some opium alkaloids, it does not have narcotic effects.
-Historically, it has been used as an antitussive (cough suppressant) due to its antitussive properties without causing the sedation associated with opiates.
Pathways:
-Mitochondrial stress, release of cytochrome c, and activation of caspases (such as caspase-3), leading to cellular apoptosis.
-Inhibit angiogenesis
-Interfere with the NF-κB signaling pathway
-Noscapine can enhance the effects of traditional chemotherapeutics when used in combination. It may help overcome drug resistance by modulating cell cycle regulators and apoptosis-related proteins.