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Verapamil belongs to the phenylalkylamine class of compounds and is a fully synthetic molecule originally developed for its potent calcium channel–blocking properties.
Pathways:
-P-glycoprotein Inhibition (MDR1). -P-gp is overexpressed in many cancer cells
-Inhibition of P-gp by verapamil can enhance the intracellular concentration of chemotherapeutic agents, potentially restoring drug sensitivity.
-As a calcium channel blocker, verapamil inhibits L-type calcium channels.