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Suberoylanilide hydroxamic acid (SAHA) (Vorinostat) is a synthetic compound. It was designed and developed as a small-molecule inhibitor targeting HDAC enzymes.
-Anticancer effects primarily through the inhibition of histone deacetylases (HDACs).
-Reactivation of tumor suppressor genes.
-Cell cycle arrest via upregulation of inhibitors like p21.