Edit Target: 313
Ukrain is often said to be based on extracts from the greater celandine plant (Chelidonium majus), which has been used in traditional medicine.
-Although its active components are derived from a natural source, the final product is processed and standardized in a pharmaceutical setting. This means Ukrain is more accurately described as a semi-synthetic or phytochemical-based drug rather than a crude natural remedy.
-Celandine sap is used to treat warts and skin cancer (98% alkaloids)
-Chelidonine (80% of alkaloids) is most important
-Claimed to affect cancer cells and not normal cells
Pathways:
-Ukrain may induce apoptosis, MMP depolarization, cyt-c release, caspase activation.
-Ukrain might increase the production of reactive oxygen species in cancer cells.
-Cell Cycle Arrest
-p53 pathway
-(MAPK) pathways
-NF-κB) signaling
-Inhibit angiogenesis
The researchers suggest there might be a probable relationship between liver injury and consumption of Chelidonium majus. https://www.ukrain.ua/
Dr. Andrejs Liepins
Memorial University of Newfoundland
Faculty of Medicine
St John's Newfoundland
Canada A1B 3V6