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γ‐Tocotrienol is one of the tocotrienol isomers in the vitamin E family.
γ‐Tocotrienol is naturally found in certain plant oils.
– Notable sources include palm oil, rice bran oil, barley, and annatto.
– Among these, annatto oil is often highlighted as a particularly rich source of tocotrienols (with γ‐tocotrienol being one of the major components).
• Relationship within the Vitamin E Family
– Tocotrienols, including the γ isomer, are one of the two classes of vitamin E compounds (the other being tocopherols).
Pathways:
-Inhibition of NF‑κB Signaling
-downregulate the PI3K/Akt signaling cascade
-inhibit STAT3 activation
-Cell Cycle Arrest
-Antioxidant and Anti‑Inflammatory Effects(reduce reactive oxygen species (ROS) levels)
-may reduce angiogenic factors such as vascular endothelial growth factor (VEGF)