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Triptolide is a diterpenoid triepoxide primarily isolated from the traditional Chinese medicinal plant Tripterygium wilfordii Hook F (commonly known as Thunder God Vine).
Pathways:
-Activation of caspases (key executioners of apoptosis)
-Disruption of mitochondrial membrane potential
-Cell Cycle Arrest
-Suppresses expression of c-myc and mitochondrial hexokinase II (HK-II) in cancer cells