Choline is an essential nutrient with key roles in brain function, liver metabolism, and cell membrane integrity. Its involvement in Alzheimer’s disease (AD) and cancer is increasingly studied due to its roles in methylation, neurotransmitter synthesis, and cell proliferation.
-Choline is a precursor to acetylcholine (ACh), a neurotransmitter critical for memory and cognition.
-AD is associated with a loss of cholinergic neurons, leading to decreased ACh levels.
-Low choline levels may impair memory and accelerate neurodegeneration.
-Dietary choline intake in humans correlates with better cognitive performance and lower risk of dementia in some cohorts.
Choline and Cancer
-Rapidly dividing cancer cells have high choline demand to support membrane biogenesis.