Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, and its dysregulation has been implicated in Alzheimer’s disease (AD).
-Altered GABA levels: Some studies report reduced GABA levels in the brain of AD patients, while others show compensatory increases in certain brain areas.
Enhancing GABAergic signaling is being explored to:
-Reduce neuronal hyperexcitability.
-Alleviate agitation, anxiety, and seizure-like activity in AD.
-Improve memory and cognition in early disease stages.
-dietary sources of GABA. They include broccoli and other cruciferous vegetables, certain peas and beans, and oat, wheat, barley, rice, tomatoes, sweet potatoes, and spinach