Hydrogen sulfide (H₂S), a gaseous signaling molecule, has been implicated in Alzheimer’s disease (AD) pathology with both neuroprotective and neurotoxic roles, depending on concentration, source, and context.
- It was found that the endogenous H2S level in the brain of AD patients was significantly lower than that of normal people.
-A cysteine-rich diet or supplementation with an appropriate amount of N-acetylcysteine is beneficial to the synthesis of H2S in the brain
-Activates Nrf2, upregulates antioxidant genes Reduces oxidative stress, neuroprotective.
-Inhibits NF-κB activation Suppresses inflammatory cytokines like TNF-α, IL-1β
-Reduces Aβ aggregation and toxicity
-Enhances cerebral blood flow