Biological Role of Vitamin B6 -can act as a potent antioxidant -Essential for the production of serotonin, dopamine, GABA, and norepinephrine. -Homocysteine regulation: B6 is a cofactor in the conversion of homocysteine to cysteine. Elevated homocysteine levels are linked to increased AD risk and brain atrophy. -Anti-inflammatory effects: B6 may modulate inflammation, a key factor in neurodegeneration. -Myelin and cognitive function: Involved in myelin formation and synaptic plasticity. -higher vitamin B6 intakes have been associated with greater grey matter volume Cognitive support / Homocysteine lowering 10–50 mg/day Often combined with B12 and folate