Vitamin B5 (Pantothenic Acid) plays several roles in the brain, and emerging evidence suggests it may be relevant to Alzheimer’s disease (AD)—particularly through its involvement in acetylcholine synthesis, energy metabolism, and oxidative stress response.
-Precursor to Coenzyme A (CoA)
-CoA is essential for mitochondrial energy production, lipid metabolism, and acetylcholine synthesis.
-CoA + choline → acetylcholine. ACh levels are reduced in AD; B5 deficiency may worsen this.
-Pantothenic acid is indirectly involved in cysteamine production, via CoA turnover.
-cysteamine can cross the BBB and increases BDNF levels.
-Pantothenic Acid (D-calcium pantothenate) Most common, stable, and well-absorbed form, water soluable
-Heat(cooking) may degrade the B5.
-Adequate Intake is 5mg/day. Target 10-15mg/day (300–900 mg/day under supervision)