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pid
Abbr	CPT-11
Name	irinotecan
Type
Features

Natural Product : CPT-11, irinotecan

Irinotecan is a chemotherapy drug widely used to treat several solid tumors. It is a semisynthetic camptothecin derivative and functions primarily as a topoisomerase I inhibitor.
-Active metabolite: SN-38 (much more potent than irinotecan itself)

Common Regimens
Regimen Components
FOLFIRI Folinic acid + 5-FU + Irinotecan
FOLFIRINOX 5-FU + Leucovorin + Irinotecan + Oxaliplatin
XELIRI / CAPIRI Capecitabine + Irinotecan

Potential strategies to sensitize tumors to irinotecan:
Strategy	       Rationale
GSH depletion	       Reduces detox of SN-38
PRDX/TXNRD stress	Lowers redox buffering
Glycolysis inhibition	Limits repair energy
PEMF / AgNPs	        ↑ ROS, ↑ drug uptake
Timing selenium	        Avoid boosting antioxidant defenses during therapy

Report of combining CPT-11 and SeNPs to increase NRF2 in normal cells(chemoprotective) and decrease NRF2 in cancer cells(chemosentization).

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