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pid
Abbr	GSH
Name	Glutathione
Type
Features

Natural Product : GSH, Glutathione

Glutathione = GSH (reduced form)
Oxidized glutathione = GSSG
GSH/GSSG ratio = key indicator of cellular redox state

-Neutralizes H₂O₂ and lipid peroxides
-Maintains redox homeostasis

Most cancers show:
-Elevated GSH levels
-Increased GSH synthesis and recycling
-High GSH/GSSG ratio

This supports:
-Survival under oxidative stress
-Resistance to chemotherapy and radiation
-Detoxification of drugs (e.g., irinotecan, cisplatin)
-Cancer cells often develop a “GSH addiction”.

Natural Products Affecting GSH
Compound	        Effect
Curcumin	        ↓ GSH in cancer cells
Sulforaphane	        Transient NRF2 activation → later depletion
Resveratrol	        Disrupts GSH recycling
Quercetin	        Consumes GSH during detox
Selenium compounds	Dose-dependent: support GPX or induce redox stress
High-dose Vitamin C	Depletes GSH via ROS overload

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