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Bicarbonate one central carbon atom surrounded by three oxygen atoms in a triogonal planer arrangement with a hydrogen atom attached to one of the oxygens.
-Bicarbonate’s primary role is in pH buffering. Its administration has been studied as an adjuvant strategy to modify the tumor microenvironment.
-Many solid tumors exhibit an acidic microenvironment due to high rates of glycolysis (the “Warburg effect”) and poor perfusion. Bicarbonate supplementation can buffer this acidity, raising the extracellular pH.
-By modulating pH, bicarbonate may influence pathways tied to glycolysis and oxidative phosphorylation