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Soursop or Brazilian paw paw or guanabana. People use fruit, roots, seeds and leaves.
Graviola, also known as Annona muricata, is a tropical fruit-bearing tree native to the Americas.
GLUT1 inhibitor?
The major pathways involved in Graviola's anti-cancer effects include:
-Inhibition of glycolysis: Graviola extracts have been shown to inhibit the activity of lactate dehydrogenase (LDH), a key enzyme involved in glycolysis, the process by which cancer cells produce energy. By inhibiting LDH, Graviola reduces the production of lactate, a key metabolite that fuels cancer cell growth.
-Inhibition of glucose uptake: Graviola extracts have also been shown to inhibit the uptake of glucose by cancer cells, further reducing their energy production.
-Inhibition of the PI3K/AKT pathway: The PI3K/AKT pathway is a key signaling pathway involved in cell survival and proliferation. Graviola extracts have been shown to inhibit this pathway, leading to reduced cancer cell growth and survival.
-Induction of apoptosis: Graviola extracts have been shown to induce apoptosis in cancer cells by activating pro-apoptotic proteins and inhibiting anti-apoptotic proteins.
The major compounds responsible for Graviola's anti-cancer effects are:
Annonaceous acetogenins: These are a group of compounds found in Graviola that have been shown to inhibit cancer cell growth and induce apoptosis.
Quercetin: A flavonoid found in Graviola that has been shown to inhibit cancer cell growth and induce apoptosis.