CaMKII Cancer Research Results

CaMKII , CAMKK, CAMKK2, Calcium/Calmodulin-dependent Protein Kinase II: Click to Expand ⟱
Source:
Type:
CaMKII, short for Calcium/Calmodulin-dependent Protein Kinase II, is not a single protein but rather a family of related enzymes composed of several isoforms.
Breakdown:
CaMKII Isoforms:4 genes encoding the major isoforms: α(alpha), β(beta), γ(gamma), and δ(delta). CaMKIIα and CaMKIIβ are abundant in neuronal tissue, while CaMKIIδ is more prevalent in the heart and other non-neuronal tissues.

-Overexpression or hyperactivation of CaMKII has been linked in some studies to enhanced cell cycle progression and resistance to apoptosis, both of which are features of more aggressive tumors.
-In some cancers, upregulation or increased activity of CaMKII has been associated with poor clinical outcomes, including lower overall survival or higher recurrence rates.

CAMKK2 (Calcium/Calmodulin-Dependent Protein Kinase Kinase 2; CaMKK2) — Calcium/calmodulin-regulated serine/threonine kinase that functions upstream of CAMK1, CAMK4, AMPK, and other signaling pathways. CAMKK2 links intracellular Ca2+ signaling to cellular metabolism, proliferation, migration, neuronal signaling, and survival.

Typical modulation in cancer: Frequently ↑ or activated in several cancers and often tumor-promoting. CAMKK2 signaling can support proliferation, metabolic adaptation, migration, invasion, androgen-receptor-associated signaling, and tumor progression. CAMKK2 inhibition is under investigation as an anticancer strategy.

Typical modulation in Alzheimer’s disease / neurobiology: Context-dependent. CAMKK2 regulates neuronal Ca2+ signaling, AMPK, neurite outgrowth, synapse formation, learning, and memory. Excessive or dysregulated Ca2+-CAMKK2 signaling may contribute to neuronal stress depending on context.

Typical mechanistic relationships: Ca2+ / calmodulin → CAMKK2 activation → CAMK1 / CAMK4 and AMPK phosphorylation → regulation of metabolism, transcription, neuronal function, proliferation, and migration.
Scientific Papers found: Click to Expand⟱
9044- PatchO,    Patchouli oil and its main component patchouli alcohol inhibit colorectal cancer by activating ectopic olfactory receptor
- vitro+vivo, CRC, HCT116
OS↑, TumCG↓, Inflam↓, AMPK↑, Ferroptosis↑, OR13G1?, CaMKII ?, TumPF↓, TumCMig↓, Tumccf↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ?, 1,   OR13G1?, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,   TumPF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CaMKII , CAMKK, CAMKK2, Calcium/Calmodulin-dependent Protein Kinase II
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1142  State#:%  Dir#:0
  wNotes=0  sortOrder:rid,rpid

 

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