ATM Cancer Research Results

ATM, similar to Serine-protein kinase ATM (Ataxia telangiectasia mutated) (A-T, mutated); ataxia telangiectasia mutated: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
ATM is considered a moderate cancer risk gene. A mutation in a moderate risk gene is just one risk factor that can contribute to cancer development. ATM has traditionally been assigned the role of a tumor suppressor. However, in both humans and mice, lymphoma and leukemia are the only clear-cut examples of cancer development caused by ATM deficiency(13). Its roles in other types of cancer, especially solid tumors, are much less clear.
ATM, a master regulator of DNA damage response.
Scientific Papers found: Click to Expand⟱
8853- DIM,    Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies
- Review, Var, NA
AhR↓, NRF2↑, *ROS↓, *p‑BRCA1↑, *COX2/PTGS2↓, CYP19↓, uPA↓, VEGF↓, MMP9↓, TumCMig↓, FOXM1↓, mTOR↓, Akt↓, radioP↑, ATM?, BioAv↑, BioAv↓, Dose↝, BioAv↑, Half-Life↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   mTOR↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

FOXM1↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,  

Migration(tgid=13) ⓘ

MMP9↓, 1,   TumCMig↓, 1,   uPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   Dose↝, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

FOXM1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

radioP↑, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

p‑BRCA1↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: ATM, similar to Serine-protein kinase ATM (Ataxia telangiectasia mutated) (A-T, mutated); ataxia telangiectasia mutated
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:20  State#:%  Dir#:0
  wNotes=0  sortOrder:rid,rpid

 

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