Th1 response Cancer Research Results

Th1 response, T helper response: Click to Expand ⟱
Source: HalifaxProj(promote)
Type:
The Th1 (T helper 1) response is a crucial component of the immune system, particularly in the context of cell-mediated immunity. Th1 cells are a subset of CD4+ T cells that primarily produce cytokines such as interferon-gamma (IFN-γ), which activate macrophages and enhance the ability of the immune system to combat intracellular pathogens, including viruses and certain types of cancer cells.

Increased infiltration of Th1 cells and a strong Th1 cytokine profile within tumors are often associated with better clinical outcomes in various cancers (including melanoma, colorectal, and ovarian cancers).

A robust Th1 response is a critical component of effective antitumor immunity. Th1 cells and their signature cytokines (such as IFN-γ and IL-2) enhance the activation and proliferation of cytotoxic T cells, macrophages, and natural killer cells, thereby promoting immune-mediated tumor cell destruction. High infiltration of Th1 cells and a strong Th1 cytokine profile within the tumor microenvironment are generally associated with favorable prognostic outcomes and improved responses to immunotherapies.


Scientific Papers found: Click to Expand⟱
8318- LIN,    Linalool Exhibits Cytotoxic Effects by Activating Antitumor Immunity
- NA, BC, T47D - NA, CRC, SW-620 - NA, Liver, HepG2
TumCCA↑, IFN-γ↓, IL13↓, IL2↓, IL4↓, IL6↓, TNF-α↓, Th1 response?,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IL13↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↓, 1,   IL2↓, 1,   IL4↓, 1,   IL6↓, 1,   Th1 response?, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Th1 response, T helper response
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:305  State#:%  Dir#:0
  wNotes=0  sortOrder:rid,rpid

 

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