toxicity Cancer Research Results

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Toxicity
Scientific Papers found: Click to Expand⟱
5278- 3BP,    The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression
- in-vitro, CRC, HCT116 - in-vitro, CRC, Caco-2 - in-vitro, CRC, SW48
ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,
5274- 3BP,    ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
- in-vitro, PC, NA
eff↑, TumCG↓, TumMeta↓, toxicity↝, Glycolysis↓, toxicity↓, Dose↝,
5259- 3BP,    Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
- in-vivo, HCC, NA
ATP↓, TumCD↑, toxicity↓, eff↑, tumCV↓, Dose↝,
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,
5269- 3BP,    The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.
- in-vitro, HCC, NA
toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,
5466- AF,    Auranofin Inhibition of Thioredoxin Reductase in a Preclinical Model of Small Cell Lung Cancer
- in-vivo, Lung, NA
TrxR↓, Dose↝, RadioS↑, ChemoSen↑, ROS↑, Diff↑, toxicity↓,
5458- AF,    Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer
- in-vitro, NSCLC, NA
TrxR↓, AntiCan↓, GPx4↓, DNAdam↑, toxicity↓, eff↝,
5468- AF,    The gold complex auranofin: new perspectives for cancer therapy
- Review, Var, NA
TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,
5436- AG,    Therapeutic Effect of Astragalus Polysaccharides on Hepatocellular Carcinoma H22-Bearing Mice
- in-vivo, HCC, NA
TumCG↓, BAX↑, Bcl-2↓, IL2↑, IL6↑, TNF-α↑, toxicity↓,
4573- AgNPs,    Bioactive silver nanoparticles derived from Carica papaya floral extract and its dual-functioning biomedical application
- in-vitro, Var, MCF7 - NA, NA, HEK293
toxicity↓, Bacteria↓, selectivity↑,
305- AgNPs,    Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer
- Case Report, HNSCC, NA
OS↑, Dose↓, BioAv↝, toxicity↓, Remission↑, other↝, other↝, other↝, Dose↝, BioAv↝,
2538- AgNPs,  SDT,  Z,    Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment
- Study, Var, NA - vitro+vivo, NA, NA
ROS↑, eff↑, eff↑, TumCP↓, toxicity↓,
2582- ART/DHA,  5-ALA,    Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity
- in-vivo, CRC, HCT116 - in-vitro, CRC, HCT116
eff↑, ROS↑, selectivity↑, TumCG↓, toxicity↓,
2001- Ash,    Withania somnifera: from prevention to treatment of cancer
- Review, Var, NA
toxicity↓, TumW↓, Dose?, eff↝, Ki-67↓, survivin↓, XIAP↓, PERK↑, p‑RSK↑, CHOP/DDIT3↑, DR5↑, Dose↝, BG↓, DNMTs↓,
5391- AsP,    Research Progress of Ascorbyl Palmitate in Drug Delivery and Cancer Therapy
- Review, Var, NA
*antiOx↑, toxicity↓,
5372- ATO,    Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia
- Trial, APL, NA
Remission↑, OS↑, toxicity↓,
5374- ATO,    A pharmacokinetic and safety study of oral arsenic trioxide in patients with acute promyelocytic leukemia
- Trial, APL, NA
toxicity↓, OS↑,
5448- ATV,    Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,
5449- ATV,    Pleiotropic effects of statins: A focus on cancer
- NA, Var, NA
lipid-P↓, TumCG↓, Apoptosis↑, ChemoSen↑, RAS↓, HMG-CoA↓, HMGCR↓, LDL↓, toxicity↓, Risk↓, P21↑, HDAC↓, Bcl-2↓, BAX↑, BIM↑, Casp↑, cl‑PARP↑, MMP↓, ROS↑, angioG↓, TumMeta↓, PTEN↑, eff↑, OS↑, Remission↑,
5249- Ba,  BA,    Baicalein and baicalin in cancer therapy: Multifaceted mechanisms, preclinical evidence, and translational challenges
- Review, Var, NA
Apoptosis↑, Inflam↓, TumCCA↑, ChemoSen↑, RadioS↑, TumCG↓, toxicity↓, BioAv↓, Half-Life↓,
5542- BBM,    Pharmacological profiling of a berbamine derivative for lymphoma treatment
- vitro+vivo, lymphoma, NA
CaMKII ↓, TumCG↓, cMyc↓, ROS↑, UPR↑, ER Stress↑, PERK↑, BioAv↑, toxicity↓,
5555- BBM,    Berbamine inhibits cell proliferation and invasion by increasing FTO expression in renal cell carcinoma cells
- vitro+vivo, RCC, NA
TumCP↓, TumCMig↓, TumCI↓, TumCG↓, toxicity↓, FTO↑,
2673- BBR,    Therapeutic potential and recent delivery systems of berberine: A wonder molecule
- Review, Var, NA
*BioAv↓, *Half-Life↓, *neuroP↑, BBB↑, toxicity↓,
6497- BCP,  Cisplatin,    Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules
- in-vitro, Lung, NA
TumCG↓, TumCP↓, Apoptosis↑, toxicity↓, ChemoSen↑, P21↑, Bcl-xL↑, Bcl-2↓, EMT↓, E-cadherin↑, eff↑, MMP↓,
5583- BetA,    Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells
- vitro+vivo, NA, NA
ROS↑, Bcl-2↓, BAX↑, TOP1↝, eff↝, toxicity↓, toxicity↓, selectivity↑,
5716- BF,    Pilot Study of Huachansu in Patients with Hepatocellular Carcinoma, Non-Small Cell Lung Cancer, or Pancreatic Cancer
- Trial, NSCLC, NA - Trial, PC, NA - Trial, HCC, NA
Dose↝, toxicity↓, other↓, QoL↑, OS?,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *eff↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp/ABCB1↓, eff↑, other↝,
5660- BNL,    Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System
- Review, Var, NA
TumMeta↓, BBB↑, EPR↑, toxicity↓, BioAv↑, ChemoSen↑, eff↑, other↑, P-gp/ABCB1↓, MDR1↓, ROS↑, TumCCA↑, other↝, BioAv↓, DNAdam↑, BioEnh↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
5698- BRU,    Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma
- in-vitro, HCC, NA
TumCMig↓, EMT↓, STAT3↓, E-cadherin↑, NRF2↓, ChemoSen↑, RadioS↑, DNAdam↑, TumCMig↓, TumCI↓, toxicity↓,
5708- Brut,    Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers
- Review, Nor, NA
*Imm↑, *cardioP↑, *LDL↓, toxicity↓,
7976- BUL,    Antitumor activity and toxicity relationship of annonaceous acetogenins
- in-vitro, HCC, H22
toxicity↓, TumCG↓, *toxicity↑, *ROS↑, *Ca+2↑, *BAX↑,
5736- Buty,    Clinical and pharmacologic study of tributyrin: an oral butyrate prodrug
- Trial, Var, NA
Dose↝, BioAv↝, toxicity↓, OS↝,
5829- CAP,    Anti-cancer activity of capsaicin and its analogs in gynecological cancers
- Review, Var, NA
Pain↓, BioAv↓, toxicity↝, toxicity↓,
5885- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, toxicity↓, *Inflam↓, AntiDiabetic↑, cardioP↑, neuroP↑, selectivity↑, Apoptosis↑, p‑Cofilin↑, F-actin↓, PI3K↓, Akt↓, MEK↓, MAPK↓,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2/PTGS2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
5953- Cela,  CUR,    The Combination of Celastrol and Curcumin Enhances the Antitumor Effect in Nasopharyngeal Carcinoma by Inducing Ferroptosis
- vitro+vivo, NPC, NA
eff↑, TumCP↓, GPx4↓, eff↑, TumAuto↑, Ferroptosis↑, Dose↝, ACSL4↑, toxicity↓,
5946- Cela,    The anti-cancer mechanism of Celastrol by targeting JAK2/STAT3 signaling pathway in gastric and ovarian cancer
- in-vitro, Var, NA
toxicity⇅, toxicity↓, TumCG↓, ROS↑, IL6↓, JAK2↓, STAT3↓,
7174- CHA,    Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma
- vitro+vivo, OS, OS-RC-2
SUV39H↓, TumCG↓, NOTCH1↓, CD31/PECAM-1↓, VEGF↓, toxicity↓, Ki-67↓, angioG↓,
7163- CHA,    The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation
- in-vitro, Lung, A549 - in-vitro, OS, U2OS - in-vitro, CRC, HCT116 - in-vitro, CRC, HeLa - in-vivo, Ovarian, SKOV3
ROS↑, Trx↓, Apoptosis↑, TumCG↓, SUV39H↓, Hif1a↓, TumCP↓, eff↓, MMP↓, TumCG↓, Dose↝, toxicity↓,
7159- CHA,    ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- vitro+vivo, GC, HGC27 - in-vitro, GC, AGS - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, HEK293
TumCP↓, TumCCA↑, Casp↑, Apoptosis↑, TrxR1↓, ROS↑, eff↓, eff↑, PI3K↓, Akt↓, TumCG↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓, TumVol↓, TumW↓, Weight∅, toxicity↓, Ki-67↓, other↝,
6000- Chit,    Chitosan in Modern Pharmacotherapy: From Drug Encapsulation to Targeted Delivery Systems
- Review, Var, NA
DDS↑, toxicity↓, TJ↓, BioAv↑, *Bacteria↓, *Inflam↓, *antiOx↓, Wound Healing↑, other↝, eff↑, eff↑,
6001- Chit,    Recent advances in engineering chitosan-based nanoplatforms in biotherapeutic multi-delivery for multi-targeted disease treatments: Promises and outlooks
- Review, Var, HepG2 - Review, AD, NA
TumVol↓, toxicity↓, Half-Life↑, eff↑, selectivity↑, Dose↝, *BDNF↑, *NRF2↑, *ROS↓, *neuroP↑, *memory↑, *cognitive↑, *Obesity↓,
5982- Chit,    Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges
- Review, Var, NA
DDS↑, antiOx↑, Bacteria↓, AntiTum↑, Half-Life↑, BioAv↑, toxicity↓,
5991- Chit,    Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies
- Review, BC, NA
*other↝, *BioAv↓, eff↑, toxicity↓, eff↑, TumCD↑, Half-Life↑, selectivity↑, EPR↑, ROS↑, Apoptosis↑, eff↑,
5996- Chit,    NEW CHITOSAN-BASED CHEMO PHARMACEUTICAL DELIVERY SYSTEMS FOR TUMOR CANCER TREATMENT: SHORT-REVIEW
- Review, Var, NA
BioAv↑, Wound Healing↑, DDS↑, toxicity↓, eff↑,
5995- Chit,  CUR,    Enhancement of anticancer activity and drug delivery of chitosan-curcumin nanoparticle via molecular docking and simulation analysis
- vitro+vivo, Var, NA
eff↑, EPR↑, DNAdam↑, TumCCA↑, ROS↑, toxicity↓,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, eff↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
4764- CoQ10,  VitE,    Auxiliary effect of trolox on coenzyme Q10 restricts angiogenesis and proliferation of retinoblastoma cells via the ERK/Akt pathway
- in-vitro, RPE, Y79 - in-vitro, Nor, ARPE-19 - in-vivo, NA, NA
tumCV↓, Apoptosis↑, ROS↑, MMP↓, TumCCA↑, VEGF↓, ERK↓, Akt↓, ChemoSen↑, chemoP↑, toxicity↓, angioG↓,

Showing Research Papers: 1 to 50 of 153
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 153

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 1,   APE1/APEX1↓, 1,   DCR↑, 1,   FBXO5/EMI1↓, 1,   IL7↓, 1,   Ingr↝, 1,   IRF1↑, 1,   LC↑, 1,   LIFR/CD118↓, 1,   miR-375↑, 1,   Mucositis↓, 1,   Nausea↓, 1,   OGF↑, 1,   OGFr↑, 1,   PC↑, 1,   PFS↓, 1,   PFS↑, 2,   PSEN1/PS1↓, 1,   RBC↑, 1,   SUV39H↓, 2,   TumNum?, 1,   Vomit↓, 1,   WBC↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↓, 1,   compI↓, 1,   Copper↓, 1,   Ferroptosis↑, 3,   GPx4↓, 3,   GSH↓, 5,   GSTA1↓, 1,   GSTZ1↓, 1,   GSTZ1↝, 1,   HO-1↓, 2,   HO-1↑, 1,   lipid-P?, 1,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↑, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 4,   NRF2↑, 1,   NRF2↝, 1,   OXPHOS↓, 1,   OXPHOS↑, 3,   mt-OXPHOS↑, 1,   ROS↓, 3,   ROS↑, 42,   mt-ROS↑, 2,   SOD↓, 2,   SOD↑, 1,   SOD1↑, 1,   SOD2↑, 1,   Trx↓, 2,   TrxR↓, 6,   TrxR1↓, 1,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 4,   ATP↓, 9,   BCR-ABL↓, 1,   CDC25↓, 1,   ETC↓, 3,   ETC↑, 1,   Insulin↓, 1,   MEK↓, 1,   mitResp↑, 1,   MKK4↓, 1,   MKK7↓, 1,   MMP↓, 17,   MMP↑, 1,   MPT↑, 3,   mtDam↑, 2,   OCR↑, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   ALAT↓, 1,   ALAT↑, 1,   AMP↓, 1,   AMP↑, 1,   AMPK↑, 1,   BUN↓, 1,   cMyc↓, 5,   CREB↓, 1,   CYP3A4↓, 1,   GAPDH↓, 1,   glucoNG↓, 1,   glucose↝, 1,   GlucoseCon↓, 1,   Glycolysis↓, 13,   HK2?, 1,   HK2↓, 4,   HMG-CoA↓, 2,   lactateProd↓, 2,   LDHA↓, 1,   LDL↓, 2,   lipoGen↓, 2,   NADH:NAD↓, 1,   PDK1 / PDPK1↓, 2,   PDKs↓, 3,   p‑PDKs↓, 1,   PFK↓, 1,   PFKFB2↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 1,   PPARα↓, 1,   TCA↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 20,   p‑Akt↓, 3,   p‑Akt↑, 1,   APAF1↑, 1,   Apoptosis↑, 49,   ATF2↓, 1,   BAD↑, 2,   BAX↑, 13,   Bax:Bcl2↑, 1,   Bcl-2↓, 16,   Bcl-xL↓, 3,   Bcl-xL↑, 1,   BID↑, 1,   BIM↑, 3,   Casp↑, 8,   Casp1↑, 1,   Casp3↑, 12,   cl‑Casp3↑, 6,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 5,   cl‑Casp8↑, 1,   Casp9↑, 4,   cl‑Casp9↑, 3,   CBP↓, 1,   Cyt‑c↑, 8,   DR4↑, 1,   DR5↑, 3,   Ferroptosis↑, 3,   GSDME↑, 1,   iNOS↓, 2,   JNK↓, 1,   MAPK↓, 2,   MAPK↑, 2,   Mcl-1↓, 3,   MDM2↓, 1,   MOMP↑, 3,   Myc↓, 1,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 2,   p38↓, 1,   p38↑, 2,   p‑p38↑, 1,   Pyro↑, 1,   p‑RSK↑, 1,   survivin↓, 9,   TRAIL↑, 1,   TumCD↑, 7,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,   cSrc↓, 1,   p‑HER2/EBBR2↓, 1,   Sp1/3/4↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

BowelM↑, 1,   ChrMod↑, 1,   cJun↓, 4,   EZH2↓, 1,   ac‑H3↑, 2,   ac‑H4↑, 1,   HATs↓, 1,   other?, 1,   other↓, 2,   other↑, 4,   other↝, 14,   pRB↓, 1,   p‑pRB↓, 2,   SD↑, 1,   tumCV↓, 12,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 3,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 5,   PERK↑, 3,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,   TumAuto↑, 9,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   DFF45↓, 1,   DNAdam↑, 10,   DNArepair↓, 1,   DNMTs↓, 2,   P53↑, 6,   PARP↓, 1,   PARP↑, 2,   cl‑PARP↑, 9,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK2↓, 9,   CDK4↓, 6,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 5,   cycD1/CCND1↓, 9,   cycE/CCNE↓, 5,   E2Fs↓, 2,   P21↓, 2,   P21↑, 5,   RB1↓, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 29,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMI1↓, 1,   cFos↓, 3,   cMET↓, 1,   CSCs↓, 10,   Diff↑, 5,   EMT↓, 8,   EpCAM↓, 1,   ERK↓, 7,   p‑ERK↓, 1,   p‑FOXO3↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 3,   HMGCR↓, 2,   Let-7↑, 1,   LRP6↓, 1,   mTOR↓, 13,   mTORC1↓, 1,   Nanog↓, 2,   NOTCH↓, 3,   NOTCH1↓, 2,   OCT4↓, 2,   p300↓, 1,   PI3K↓, 14,   p‑PI3K↓, 2,   PTEN↑, 3,   RAS↓, 5,   Smo↓, 1,   SOX2↓, 2,   STAT↓, 3,   STAT3↓, 16,   STAT4↑, 1,   STAT5↓, 1,   TOP1↓, 2,   TOP1↝, 1,   TOP2↓, 1,   TOP2↑, 1,   TRPM7↓, 1,   TumCG?, 1,   TumCG↓, 40,   Wnt↓, 6,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   i-Ca+2↓, 1,   CD31/PECAM-1↓, 2,   CDK4/6↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 1,   E-cadherin↑, 6,   F-actin↓, 1,   fascin↓, 1,   FTO↑, 1,   GLI3↓, 1,   Ki-67↓, 7,   KRAS↓, 1,   miR-200b↑, 1,   MMP1↓, 2,   MMP2↓, 7,   MMP3↓, 2,   MMP9↓, 11,   MMPs↓, 2,   N-cadherin↓, 4,   PDGF↓, 1,   PKCδ↓, 1,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 2,   TIMP1↑, 1,   TJ↓, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 16,   TumCMig↓, 13,   TumCP↓, 31,   TumCP∅, 1,   TumMeta↓, 13,   TumMeta↑, 1,   Twist↓, 2,   Vim↓, 3,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 25,   ATF4↑, 1,   EGFR↓, 4,   Endoglin↓, 1,   EPR↑, 6,   HIF-1↓, 1,   Hif1a↓, 10,   Hypoxia↓, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 13,   VEGFR2/KDR/Flk1↓, 2,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   GLUT4↓, 1,   P-gp/ABCB1↓, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 7,   COX2/PTGS2↑, 2,   CXCR4↓, 2,   DCells↑, 1,   IKKα↓, 3,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 2,   IL1β↑, 1,   IL2↑, 1,   IL22↓, 1,   IL6↓, 7,   IL6↑, 1,   IL8↓, 1,   Imm↑, 11,   INF-γ↝, 1,   Inflam↓, 7,   JAK↓, 1,   JAK1↓, 3,   JAK2↓, 4,   MCP1/CCL2↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   Neut↑, 1,   NF-kB↓, 17,   NF-kB↑, 1,   p‑NF-kB↓, 1,   NK cell↑, 7,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 4,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 1,   TNF-α↓, 5,   TNF-α↑, 1,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH∅, 1,   e-pH↓, 1,   e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   AR↝, 1,   CDK6↓, 2,   CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 20,   BioAv↝, 10,   BioEnh↑, 1,   ChemoSen↑, 32,   CYP17A1↓, 1,   DDS↑, 4,   Dose?, 1,   Dose↓, 4,   Dose↑, 8,   Dose↝, 50,   Dose∅, 5,   eff↓, 8,   eff↑, 72,   eff↝, 10,   Half-Life↓, 5,   Half-Life↑, 4,   Half-Life↝, 2,   MDR1↓, 1,   RadioS↑, 22,   selectivity↑, 27,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALAT↑, 1,   AR↓, 4,   AR↝, 1,   ascitic↓, 1,   AST↓, 1,   AST↑, 1,   BG↓, 1,   BloodF↑, 1,   BRCA1↓, 1,   CA125↓, 1,   creat↓, 1,   EGFR↓, 4,   EZH2↓, 1,   Hcy/homoC↓, 1,   p‑HER2/EBBR2↓, 1,   IL6↓, 7,   IL6↑, 1,   Ki-67↓, 7,   KRAS↓, 1,   Myc↓, 1,   PD-L1↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 12,   AntiDiabetic↑, 1,   antiNeop↑, 1,   AntiTum↑, 4,   Appetite↑, 1,   breath↑, 1,   cardioP↑, 4,   chemoP↑, 9,   chemoP∅, 1,   chemoPv↑, 5,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 1,   hepatoP↑, 4,   hepatoP↝, 1,   hepatoP∅, 1,   neuroP↑, 2,   NP/CIPN↓, 1,   NP/CIPN↑, 1,   OS?, 1,   OS↑, 20,   OS⇅, 1,   OS↝, 1,   Pain↓, 3,   QoL↑, 7,   QoL∅, 1,   radioP↑, 2,   Remission↑, 8,   RenoP↑, 1,   Risk↓, 5,   Risk↑, 1,   Risk∅, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 156,   toxicity↑, 5,   toxicity⇅, 1,   toxicity↝, 9,   TumVol↓, 13,   TumW↓, 10,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,   CD8+↑, 2,  
Total Targets: 456

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   diuretic↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 9,   ARE↑, 1,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 2,   HO-1↑, 3,   Iron∅, 1,   lipid-P↓, 3,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 4,   ROS↓, 7,   ROS↑, 1,   SOD↑, 3,   SOD2↑, 1,   xCT/SLC7A11↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   LDL↓, 1,   NADPH↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Casp1↓, 1,   iNOS↓, 1,   MAPK↓, 1,   MAPK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   Ca+2↝, 1,   β-Endo↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EPR↑, 1,   NO↓, 2,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 3,   Imm↑, 3,   Inflam↓, 10,   IκB?, 1,   NF-kB↓, 4,   PGE2↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioAv↝, 3,   Dose↝, 1,   eff↑, 3,   Half-Life↓, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 3,   cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 4,   memory↑, 1,   neuroP↑, 6,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   RenoP↑, 1,   toxicity↑, 3,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 4,  
Total Targets: 76

Scientific Paper Hit Count for: toxicity, toxicity
7 chitosan
6 Curcumin
6 Dichloroacetate
6 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
5 3-bromopyruvate
4 Fenbendazole
3 Auranofin
3 Silver-NanoParticles
3 chaetocin
3 itraconazole
3 Lactoferrin/Talactoferrin
3 Niclosamide (Niclocide)
3 Sulfasalazine
3 Selenite (Sodium)
2 Zinc
2 Artemisinin
2 Arsenic trioxide
2 Atorvastatin
2 Berbamine
2 borneol
2 Capsaicin
2 Celastrol
2 Vitamin E
2 Radiotherapy/Radiation
2 Dandelion Root
2 Disulfiram
2 Ginger/6-Shogaol/Gingerol
2 Honokiol
2 Indole-3-carbinol
2 Inositol
2 Isoliquiritigenin
2 isoflavones
2 Licochalcone A
2 metronomic chemo
2 Magnetic Field Rotating
2 Bicarbonate(Sodium)
2 Phenylbutyrate
2 Piperine
2 Piperlongumine
2 Quercetin
2 tetrathiomolybdate
1 Astragalus
1 SonoDynamic Therapy UltraSound
1 5-Aminolevulinic acid
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Baicalein
1 Baicalin
1 Berberine
1 Beta-Caryophyllene
1 Cisplatin
1 Betulinic acid
1 Bufalin/Huachansu
1 Boswellia (frankincense)
1 brusatol
1 Bruteridin(bergamot juice)
1 Bullatacin
1 Butyrate
1 Carvacrol
1 Celecoxib
1 Cinnamon
1 Hydroxycinnamic-acid
1 Coenzyme Q10
1 Cucurbitacin
1 CUSP9
1 Cynaropicrin
1 Deguelin
1 D-limonene
1 Copper and Cu NanoParticles
1 Echinacea
1 Folic Acid, Vit B9
1 ferumoxytol
1 Formononetin
1 Fucoidan
1 Gambogic Acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Vitamin D3
1 Ginkgolide B
1 Ginkgetin
1 Gossypol/AT-101
1 Graviola
1 Hyperthermia
1 HydroxyTyrosol
1 imatinib
1 Inulin Prebiotic
1 Lasiodin
1 low dose naltrexone
1 Licorice
1 Metformin
1 Magnetic Fields
1 Phenethyl isothiocyanate
1 Propyl gallate
1 Plumbagin
1 probiotics
1 Bifidobacterium
1 Psoralidin
1 Pterostilbene
1 EGCG (Epigallocatechin Gallate)
1 Resveratrol
1 Selenium
1 Oxygen, Hyperbaric
1 Selenium NanoParticles
1 Chemotherapy
1 Anti-oxidants
1 Urolithin
1 Vitexin
1 Xylitol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1025  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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