TGFβR1 Cancer Research Results

TGFβR1, transforming growth factor-beta receptor type I: Click to Expand ⟱
Source:
Type:
TGFβR1 (transforming growth factor-beta receptor type I) is a key signaling receptor in the TGF-β pathway. This pathway is well known for its dual roles in cancer—it can act as a tumor suppressor in normal and early-stage malignant cells but may promote tumor progression and metastasis in later stages.

Often overexpressed
Increased expression correlates with aggressive behavior and reduced survival.

Tumor Suppressor Versus Promoter:
Early Stages: TGF-β signaling, through receptors like TGFβR1, can inhibit cell proliferation and induce apoptosis; hence, loss or reduced signaling in early stages may contribute to tumor initiation.
Advanced Stages: Many tumors hijack the TGF-β pathway to enhance invasive properties, suppress immune responses, and promote metastasis. In these situations, overexpression of TGFβR1 can contribute to a more aggressive phenotype.
Scientific Papers found: Click to Expand⟱
9206- BITC,    Inhibitory effects of benzyl isothiocyanate on the proliferation of prostate and breast cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
Dose↝, tumCV↓, TumCP↓, eff↝, survivin↓, TGFβR1↓, Casp3↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Casp3↑, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↝, 1,  

Functional Outcomes(tgid=23) ⓘ

TGFβR1↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TGFβR1, transforming growth factor-beta receptor type I
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1098  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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