5HT Cancer Research Results

5HT, Serotonin: Click to Expand ⟱
Source:
Type:
Serotonin (5-hydroxytryptamine or 5-HT) is best known as a neurotransmitter; however, it also plays diverse roles in peripheral tissues, including modulation of cell proliferation, angiogenesis, and immune responses.

Several studies have identified the expression of multiple 5-HT receptors (e.g., 5-HT1A, 5-HT2A, and 5-HT7) in breast cancer cells.
Serotonin may promote tumor cell proliferation and can influence breast cancer progression through receptor-mediated signaling pathways.

Expression of 5-HT and its receptors is documented in various cancers including breast, colorectal, pancreatic, prostate, and hepatocellular carcinoma.
Overexpression of particular 5-HT receptors often correlates with increased cell proliferation, angiogenesis, and metastatic potential.
High levels of 5-HT receptor expression generally serve as a marker for poor prognosis, although the exact prognostic implications vary depending on the specific receptor subtype and tumor type.

-Vomiting caused by chemotherapy was thought to result from the fact that the chemotherapeutics stimulated the secretion of 5-HT in intestinal chromaffin cells, and then 5-HT acted on 5-HT receptor which caused excitation of nerves and vomiting reflex.
Scientific Papers found: Click to Expand⟱
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
6235- CUSP9,    Exhaustive in vitro evaluation of the 9-drug cocktail CUSP9 for treatment of glioblastoma
- in-vitro, GBM, NA
tumCV↓, NF-kB↓, HH↓, 5HT↓,
1509- SFN,    Combination therapy in combating cancer
- Review, NA, NA
NRF2↑, ChemoSideEff↓, eff↑, TumCP↓, Apoptosis↑, TumCCA↑, eff↑, PSA↓, P53↑, Hif1a↓, CAIX/CA9↓, chemoR↓, 5HT↓,
1513- SFN,  acetaz,    Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis
- in-vitro, BrCC, H720 - in-vivo, BrCC, NA - in-vitro, BrCC, H727
eff↑, tumCV↓, Apoptosis↑, P21↑, PI3K↓, Akt↓, mTOR↓, 5HT↓, NRF2↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

lipid-P?, 1,   NRF2↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CAIX/CA9↓, 1,   PPARα↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 2,   Casp3↑, 1,   Casp8↑, 1,   DR4↑, 1,   DR5↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   p‑RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↓, 1,   HH↓, 1,   Let-7↑, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 1,   TOP1↓, 1,   TOP2↑, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

miR-200b↑, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP9↓, 1,   PDGF↓, 1,   TumCI↓, 1,   TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CXCR4↓, 1,   IKKα↓, 1,   IL1α↓, 1,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 2,   PSA↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   chemoR↓, 1,   ChemoSen↑, 1,   Dose↑, 1,   eff↑, 7,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   ascitic↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   toxicity↓, 1,  
Total Targets: 66

Pathway results for Effect on Normal Cells:


Cell Death(tgid=5) ⓘ

MAPK↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: 5HT, Serotonin
2 Sulforaphane (mainly Broccoli)
1 Boswellia (frankincense)
1 CUSP9
1 acetazolamide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1119  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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