Insulin Cancer Research Results

Insulin, Insulin: Click to Expand ⟱
Source:
Type:
Insulin, traditionally known for its role in regulating blood glucose levels, also exerts potent mitogenic (cell division–promoting) effects.

Insulin exerts its effects primarily through binding to the insulin receptor (IR), a receptor tyrosine kinase. Upon binding, the receptor undergoes autophosphorylation and activates several downstream signaling cascades, including:
-PI3K/Akt Pathway: Overactivation of this pathway is often observed in cancers.
-RAS/MAPK Pathway: aberrant activation can lead to tumorigenesis.

IR-A: Often predominates in fetal tissues and some cancer cells. It has a higher affinity for insulin-like growth factors (IGFs) and is more mitogenic.
IR-B: More involved in metabolic regulation.

Studies have shown that many cancers (such as breast, colon, and lung cancers) preferentially overexpress the IR-A isoform.
Scientific Papers found: Click to Expand⟱
2761- BetA,    Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
- in-vivo, Nor, NA
Insulin↓, IGF-1↓, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *antiOx?,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
1855- dietFMD,    Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study
- Trial, NA, NA
ChemoSideEff↓, QoL↑, IGF-1↓, Insulin↓,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27/CDKN1B↑, Insulin↓, IGF-1↓,
5066- dietSTF,    Intermittent and Periodic Fasting, Hormones, and Cancer Prevention
- Review, Var, NA
IGF-1↓, OS↑, AntiAge↑, glucose↓, Insulin↓,
5069- dietSTF,    The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases
- Review, Var, NA
Risk↓, ChemoSen↑, RadioS↑, *Dose↝, *Dose↝, *Dose↝, *LDL↓, *CRP↓, *TNF-α↓, TumAuto↓, GLUT1↓, GLUT2↓, glucose↓, IGF-1↓, Insulin↓, mTOR↓, mTORC1↓, AMPK↑, Warburg↓, OXPHOS↑, ROS↑, DNAdam↑, JAK1↓, STAT↓, TumCP↓, QoL↑,
5235- Ex,    Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men
- Trial, Nor, NA
Insulin↓, IGF-1↓, IGFBP1↑, eff↑,
5064- Ex,    Insulin,_Igfs.996.aspx">Effect Of Exercise Intervention On Insulin, Igfs And Igfbps In Cancer Patients
- Review, Var, NA
IGF-1↓, IGF-2↓, Insulin↓,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, eff↑,

Showing Research Papers: 1 to 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PSEN1/PS1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSH↑, 1,   HO-1↓, 1,   OXPHOS↑, 2,   ROS↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   Insulin↓, 11,   Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   glucose↓, 2,   glucose↝, 1,   GLUT2↓, 1,   Glycolysis↓, 1,   lipoGen↓, 1,   polyA↓, 1,   SIRT1↑, 1,   TS↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Bak↑, 1,   Casp9↑, 1,   MAPK↓, 1,   p27/CDKN1B↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,   p‑pRB↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   Beclin-1/ATG6↑, 1,   LAMP2↑, 1,   p62↑, 1,   TumAuto↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   ERK↓, 1,   HDAC↓, 1,   IGF-1↓, 8,   IGF-1↑, 1,   IGF-2↓, 1,   IGFBP1↑, 1,   mTOR↓, 1,   mTORC1↓, 1,   NOTCH1↓, 1,   PI3K↓, 1,   STAT↓, 1,   STAT5↓, 1,   TumCG↓, 2,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Cofilin↓, 1,   E-cadherin↑, 1,   fascin↓, 1,   MMPs↓, 1,   N-cadherin↓, 1,   ROCK1↓, 1,   Snail↓, 1,   Treg lymp↓, 1,   TumCP↓, 2,   β-catenin/ZEB1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Imm↑, 1,   JAK1↓, 1,   M2 MC↓, 1,   NF-kB↓, 1,   NK cell↑, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↓, 1,   ChemoSen↑, 3,   Dose↑, 2,   Dose↝, 3,   eff↑, 6,   eff↝, 1,   RadioS↑, 3,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 2,   GutMicro↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 3,   OS↑, 2,   QoL↑, 3,   QoL∅, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 91

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↑, 1,   Catalase↑, 1,   GSH↑, 2,   lipid-P↓, 1,   MDA↓, 1,   OXPHOS↑, 1,   ROS↓, 2,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GlucoseCon↑, 1,   LDL↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CRP↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 3,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity∅, 1,  
Total Targets: 16

Scientific Paper Hit Count for: Insulin, Insulin
3 diet FMD Fasting Mimicking Diet
2 diet Short Term Fasting
2 Exercise
1 Betulinic acid
1 Chemotherapy
1 diet Methionine-Restricted Diet
1 Inositol
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1190  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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