MCU Cancer Research Results

MCU, mitochondrial calcium uniporter: Click to Expand ⟱
Source:
Type:
Mitochondrial calcium uniporter (MCU) is a highly selective channel complex located in the inner mitochondrial membrane.
-MCU facilitates the uptake of calcium (Ca²⁺) into the mitochondrial matrix, a process that is crucial for regulating mitochondrial metabolism, cell signaling, and apoptosis.
-Mitochondrial Ca²⁺ uptake via MCU plays a key role in stimulating metabolic enzymes in the tricarboxylic acid (TCA) cycle, thereby influencing energy production.

-Overexpression of MCU has been linked in some studies to enhanced Ca²⁺ uptake, metabolic changes, and increased tumor cell migration.
-In this context, higher MCU levels (or enhanced activity) have been associated with more aggressive tumor behavior and poorer outcomes, although findings may vary with tumor subtype.
Scientific Papers found: Click to Expand⟱
2315- Citrate,  immuno,    Why and how citrate may sensitize malignant tumors to immunotherapy
- Review, Var, NA
Bcl-2↓, Mcl-1↓, survivin↓, Casp3↑, Casp9↑, Ferroptosis↑, lipid-P↑, Ca+2↓, Akt↓, mTOR↓, Hif1a↓, MCU↓, ATP↓, ROS↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   lipid-P↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

MCU↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   Ferroptosis↑, 1,   Mcl-1↓, 1,   survivin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MCU, mitochondrial calcium uniporter
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1292  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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