AChE Cancer Research Results

AChE, acetylcholinesterase: Click to Expand ⟱
Source:
Type:
AChE is an enzyme that rapidly hydrolyzes the neurotransmitter acetylcholine into choline and acetate, terminating cholinergic signals.
- In some cancers, studies have reported reduced AChE activity, which may contribute to an accumulation of acetylcholine.
- Lower levels or loss of AChE expression/activity have been associated with more aggressive tumor behavior and poor prognosis, possibly due to unchecked cholinergic signaling.

For AD (Alzheimer's), AChE inhibitors are used, to allow ACh, and ChAT to increase along with acetyl-CoA
-Natural AChE inhibitors: Ferulic Acid, Caffeic Acid, Rosmarinic Acid, Sage
-AChE inhibitors only temporarily relieve some of the disease’s cognitive symptoms and do not stop the patient’s cognitive loss
-adverse effects such as disorientation, falls, dizziness, and fatigue may occur with these medications and should be used only as recommended

- Natural AChE inhibitors paper
Scientific Papers found: Click to Expand⟱
7090- GAR,    Garcinol
AChE↓, BChE↓, *Inflam↓, *5LO↓, *PGE2↓, *antiOx↑, FAK↓, DNAdam↑, MMP↓, Casp↑, NF-kB↓, HATs↓, *toxicity↓,
3757- RosA,  Sage,  Cro,  NarG,  Caff  Food-derived Acetylcholinesterase Inhibitors as Potential Agents against Alzheimer’s Disease
- Review, AD, NA
AChE↓,
3316- SIL,  Chemo,    Silymarin Nanoparticles Counteract Cognitive Impairment Induced by Doxorubicin and Cyclophosphamide in Rats; Insights into Mitochondrial Dysfunction and Nrf2/HO-1 Axis
Inflam↓, antiOx↓, neuroP↑, cognitive↑, NRF2↑, HO-1↑, memory↑, AChE↓, Casp3↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   HO-1↑, 1,   NRF2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Casp↑, 1,   Casp3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HATs↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Migration(tgid=13) ⓘ

FAK↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BChE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   PGE2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: AChE, acetylcholinesterase
1 Garcinol
1 Rosmarinic acid
1 Salvia officinalis
1 Crocetin
1 Naringin
1 Caffeine
1 Silymarin (Milk Thistle) silibinin
1 Chemotherapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1329  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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