Hif1a Cancer Research Results

Hif1a, HIF1α/HIF1a: Click to Expand ⟱
Source:
Type:
Hypoxia-Inducible-Factor 1A (HIF1A gene, HIF1α, HIF-1α protein product)
-Dominantly expressed under hypoxia(low oxygen levels) in solid tumor cells
-HIF1A induces the expression of vascular endothelial growth factor (VEGF)
-High HIF-1α expression is associated with Poor prognosis
-Low HIF-1α expression is associated with Better prognosis

-Functionally, HIF-1α is reported to regulate glycolysis, whilst HIF-2α regulates genes associated with lipoprotein metabolism.
-Cancer cells produce HIF in response to hypoxia in order to generate more VEGF that promote angiogenesis

Key mediators of aerobic glycolysis regulated by HIF-1α.
-GLUT-1 → regulation of the flux of glucose into cells.
-HK2 → catalysis of the first step of glucose metabolism.
-PKM2 → regulation of rate-limiting step of glycolysis.
-Phosphorylation of PDH complex by PDK → blockage of OXPHOS and promotion of aerobic glycolysis.
-LDH (LDHA): Rapid ATP production, conversion of pyruvate to lactate;

HIF-1α Inhibitors:
-Curcumin: disruption of signaling pathways that stabilize HIF-1α (ie downregulate).
-Resveratrol: downregulate HIF-1α protein accumulation under hypoxic conditions.
-EGCG: modulation of upstream signaling pathways, leading to decreased HIF-1α activity.
-Emodin: reduce HIF-1α expression. (under hypoxia).
-Apigenin: inhibit HIF-1α accumulation.
Scientific Papers found: Click to Expand⟱
4774- 5-FU,  TQ,  CoQ10,    Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation
- in-vitro, CRC, NA
AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27/CDKN1B↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,
7979- AAS/EEAA,    Anti-angiogenic potential of an ethanol extract of Annona atemoya seeds in vitro and in vivo
- vitro+vivo, Nor, HUVECs - in-vitro, Lung, H460
*angioG↓, VEGF↓, Hif1a↓,
5468- AF,    The gold complex auranofin: new perspectives for cancer therapy
- Review, Var, NA
TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,
4561- AgNPs,  VitC,    Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts
- in-vitro, CRC, HCT116 - in-vitro, Nor, HEK293
NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP/DDIT3↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,
366- AgNPs,    Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis
- in-vitro, BC, MCF7
HIF-1↓, Hif1a↓, VEGF↓, GLUT1↓,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2/PTGS2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
7393- Amla,    Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors
- vitro+vivo, Ovarian, OVCAR-3 - in-vitro, Ovarian, SW626
TumCP↓, Beclin-1/ATG6↑, LC3B-II↑, Hif1a↓, Dose↝, TumAuto↑, angioG↓, COL4A3↓, CXCL6/GCP-2↓, TYMP/ECGF1↓, IL1β↓, PDGFRB↓, ChemoSen↑, Dose↝,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, NA, NA
NRF2↑, COX2/PTGS2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
958- Api,    Apigenin suppresses tumor angiogenesis and growth via inhibiting HIF-1α expression in non-small cell lung carcinoma
- in-vitro, Lung, NCIH1299
Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, PDGF↓, angioG↓,
176- Api,    Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells
- in-vitro, BC, BT474
cl‑Casp8↑, cl‑Casp3↑, p‑JAK1↓, p‑JAK2↓, p‑STAT3↓, P53↑, VEGF↓, Hif1a↓, MMP9↓, TumCG↓, TumCCA↑, cl‑PARP↑,
2631- Api,    Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
- in-vivo, GC, NA - in-vitro, GC, AGS
ER Stress↑, Hif1a↓, EZH2↓, HDAC↓, TumAuto↑, p‑mTOR↓, AMPKα↑, GRP78/BiP↑, ROS↑, MMP↓, Ca+2↑, ATF4↑, CHOP/DDIT3↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2319- Api,    Apigenin sensitizes radiotherapy of mouse subcutaneous glioma through attenuations of cell stemness and DNA damage repair by inhibiting NF-κB/HIF-1α-mediated glycolysis
- in-vitro, GBM, NA
Glycolysis↓, NF-kB↓, p65↓, Hif1a↓, GLUT1↓, GLUT3↓, PKM2↓, RadioS↑, TumVol↓, TumW↓,
2299- Api,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
TumCP↓, angioG↓, Hif1a↓, VEGF↓, GLUT1↓, PKM2↓, Glycolysis↓,
1553- Api,    Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
- Review, NA, NA
Dose∅, TumVol↓, Dose∅, COX2/PTGS2↓, Hif1a↓, TumCCA↑, P53↑, P21↑, Casp3↑, DNAdam↑, TumAuto↝,
1548- Api,    A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms
- Review, Colon, NA
*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, NA, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, eff↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, eff↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
1537- Api,    Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer
- Review, PC, NA
TumCP↓, TumCCA↑, Apoptosis↑, MMPs↓, Akt↓, *BioAv↑, *BioAv↓, Half-Life∅, Hif1a↓, GLUT1↓, VEGF↓, ChemoSen↑, ROS↑, Bcl-2↓, Bcl-xL↓, BAX↑, BIM↑,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, VEGFR2/KDR/Flk1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27/CDKN1B↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
957- ART/DHA,    Artemisinin inhibits the development of esophageal cancer by targeting HIF-1α to reduce glycolysis levels
- in-vitro, ESCC, KYSE150 - in-vitro, ESCC, KYSE170
TumCP↓, TumMeta↓, Glycolysis↓, N-cadherin↓, PKM2↓, Hif1a↓,
985- ART/DHA,    Artemisinin suppresses aerobic glycolysis in thyroid cancer cells by downregulating HIF-1a, which is increased by the XIST/miR-93/HIF-1a pathway
- in-vitro, Thyroid, TPC-1 - Human, NA, NA
XIST↓, Hif1a↓, Glycolysis↓, TumCCA↑, TumMeta↓,
2324- ART/DHA,    Research Progress of Warburg Effect in Hepatocellular Carcinoma
- Review, Var, NA
PKM2↓, GLUT1↓, Glycolysis↓, Akt↓, mTOR↓, Hif1a↓, HK2↓, LDH↓, NF-kB↓,
5398- Ash,    Withaferin-A inhibits colorectal cancer growth and metastasis by targeting the HSP90/HIF-1α/EMT axis
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
TumCG↓, TumCMig↓, TumCI↓, HSP90↓, Hif1a↓, EMT↓,
3177- Ash,    Emerging Role of Hypoxia-Inducible Factors (HIFs) in Modulating Autophagy: Perspectives on Cancer Therapy
- Review, Var, NA
Hif1a↓, ROS↑, ER Stress↑,
1358- Ash,    Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, eff↑, ChemoSen↑, ChemoSen↑, eff↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,
1180- Ash,    Withaferin A Inhibits Liver Cancer Tumorigenesis by Suppressing Aerobic Glycolysis through the p53/IDH1/HIF-1α Signaling Axis
- in-vitro, Liver, HepG2
IDH1↑, Glycolysis↓, P53↑, Hif1a↓,
5452- ATV,    Mevalonate pathway in pancreatic ductal adenocarcinoma: mechanisms driving metabolic and cellular plasticity
- Review, Var, NA
ChemoSen↑, HMG-CoA↓, EMT↓, Ferroptosis↑, Hif1a↓,
996- Ba,  Tam,    Baicalein resensitizes tamoxifen‐resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia‐inducible factor‐1α
Hif1a↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, lact/pyru↓, ROS↑, Apoptosis↑,
2474- Ba,    Anticancer properties of baicalein: a review
- Review, Var, NA - in-vitro, Nor, BV2
ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2/PTGS2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,
2620- Ba,    Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review
- Review, GC, NA
Hif1a↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, p‑Akt↓, PTEN↑, GlucoseCon↓, lactateProd↓, Glycolysis↓,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2/KDR/Flk1↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2615- Ba,    The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
- Review, Var, NA
*AntiCan↓, *Inflam↓, TumCP↓, NF-kB↓, PPARγ↑, TumCCA↑, JAK2↓, STAT3↓, TumCMig↓, Glycolysis↓, MMP2↓, MMP9↓, selectivity↑, VEGF↓, Hif1a↓, cMyc↓, ChemoSen↑, ROS↑, p‑mTOR↓, PTEN↑,
2289- Ba,  Rad,    Baicalein Inhibits the Progression and Promotes Radiosensitivity of Esophageal Squamous Cell Carcinoma by Targeting HIF-1A
- in-vitro, ESCC, KYSE150
TumCP↓, TumCMig↓, Glycolysis↓, cycD1/CCND1↓, CDK4↓, ECAR↓, TumCCA↑, HK1↓, ALDH↓, ALDOA↓, PKM2↓, Hif1a↓,
2295- Ba,  5-FU,    Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway
- in-vitro, GC, AGS
ChemoSen↑, HK2↓, LDHA↓, PDK1 / PDPK1↓, Akt↓, PTEN↑, Hif1a↓, Glycolysis↓, ROS↑, CHOP/DDIT3↑,
2297- Ba,    Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – A potential contribution to the predictive, preventive, and personalized medicine
- Review, Var, NA
Glycolysis↓, Hif1a↓, PKM2↓, RadioS↑,
2298- Ba,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
TumCG↓, TumCP↓, Hif1a↓, VEGF↓, ChemoSen↑, Glycolysis↓, HK2↓, PDK1 / PDPK1↓, LDHA↓, p‑Akt↓, PTEN↑,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
2291- Ba,  BA,    Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Melanoma, A375
LDHA↓, ENO1↓, PKM2↓, GLUT1↓, GLUT3↓, HK2↓, PFK1↓, GPI↓, TPI↓, GlucoseCon↓, TumCG↓, TumCP↓, mTORC1↓, Hif1a↓, Ki-67↓,
2391- Ba,    Scutellaria baicalensis and its flavonoids in the treatment of digestive system tumors
- Review, GC, NA
Hif1a↓, PKM2↓, RadioS↑, Glycolysis↓, PAK↓,
1392- BBR,    Based on network pharmacology and experimental validation, berberine can inhibit the progression of gastric cancer by modulating oxidative stress
- in-vitro, GC, AGS - in-vitro, GC, MKN45
TumCG↓, TumCMig↓, ROS↑, MDA↑, SOD↓, NRF2↓, HO-1↓, Hif1a↓, EMT↓, Snail↓, Vim↓,
1399- BBR,  Rad,    Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review
- Review, NA, NA
*ROS↓, *MDA↓, *TNF-α↓, *TGF-β↓, *IL10↑, ROS↑, DNAdam↑, mtDam↑, MMP↓, Apoptosis↑, TumCCA↑, Hif1a↓, VEGF↓, RadioS↑,
2695- BBR,    The effects of Berberis vulgaris consumption on plasma levels of IGF-1, IGFBPs, PPAR-γ and the expression of angiogenic genes in women with benign breast disease: a randomized controlled clinical trial
- Trial, BC, NA
IGF-1↓, PPARγ↓, VEGF↓, Hif1a↓, angioG↓,
2708- BBR,    Berberine decelerates glucose metabolism via suppression of mTOR‑dependent HIF‑1α protein synthesis in colon cancer cells
- in-vitro, CRC, HCT116
TumCG↓, GlucoseCon↓, GLUT1↓, LDHA↓, HK2↓, Hif1a↓, mTOR↓, Glycolysis↓,
2709- BBR,    Berberine inhibits the glycolysis and proliferation of hepatocellular carcinoma cells by down-regulating HIF-1α
- in-vitro, HCC, HepG2
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Glycolysis↓, Hif1a↓, GLUT1↓, HK2↓, PKM2↓, LDHA↓,

Showing Research Papers: 1 to 50 of 295
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 295

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AApath↓, 1,   ACE/ACE1↓, 1,   p‑AMT/GCST/T-protein↑, 1,   ATG13↑, 1,   ATG16L1↑, 1,   CD47↓, 1,   COL4A3↓, 1,   CXCL6/GCP-2↓, 1,   ERCC4/XPF↓, 1,   HES1↓, 2,   ILK↓, 1,   Ku70/XRCC6↓, 1,   miR-122-5p↑, 1,   miR-124-3p↓, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-326-5p↑, 1,   miR-339-5p↝, 1,   miR-375↑, 1,   miR-590-3p↑, 1,   MMP16↓, 1,   NA↓, 1,   PFS↑, 1,   RUBCN↓, 1,   SUV39H↓, 3,   THEM4/CTMP↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TYMP/ECGF1↓, 1,   ULK1/ATG1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 7,   antiOx⇅, 1,   ATF3↑, 1,   Catalase↓, 2,   Catalase↑, 2,   compI↓, 1,   CYP1A1↓, 4,   CYP1A1↑, 1,   CYP2E1↑, 1,   Fenton↑, 2,   Ferroptosis↑, 10,   frataxin↑, 1,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 2,   GPx4↑, 1,   GSH↓, 10,   GSH↑, 4,   GSTs↑, 2,   GSTZ1↓, 1,   H2O2↓, 3,   H2O2↑, 3,   HK1↓, 1,   HO-1↓, 7,   HO-1↑, 8,   HO-2↓, 1,   Iron↑, 2,   Iron∅, 1,   lipid-P↓, 3,   lipid-P↑, 7,   MAD↓, 1,   MDA↓, 1,   MDA↑, 3,   MPO↓, 3,   NADH↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↓, 15,   NRF2↑, 20,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 6,   mt-OXPHOS↓, 2,   PrxI↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 17,   ROS↑, 107,   ROS⇅, 4,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   RPM↑, 1,   SIRT3↓, 2,   SIRT3↑, 5,   SOD↓, 4,   SOD↑, 5,   SOD2↓, 2,   SOD2↑, 1,   TKT↝, 1,   Trx↓, 1,   ox-Trx1↑, 1,   TrxR↓, 5,   TrxR1↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   AIF↑, 4,   ATP↓, 21,   ATP↑, 2,   ATP↝, 1,   i-ATP↓, 1,   BCR-ABL↓, 1,   BOK↑, 1,   CDC2↓, 1,   CDC25↓, 2,   EGF↓, 1,   ETC↓, 3,   MEK↓, 4,   mitResp↓, 4,   MKK4↓, 1,   MKK7↓, 1,   MMP↓, 47,   MMP↑, 1,   Mortalin↓, 1,   MPT↑, 2,   mtDam↑, 7,   OCR↓, 6,   OCR↑, 3,   PGC-1α↑, 2,   Raf↓, 3,   c-Raf↓, 1,   SDH↓, 1,   XIAP↓, 14,   XIAP↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ACC↓, 1,   ACLY↓, 1,   AKT1↓, 2,   ALAT↓, 1,   ALAT↝, 1,   ALDOA↓, 1,   AMACR↓, 1,   AMP↓, 1,   AMPK↑, 16,   p‑AMPK↑, 3,   ATG7↑, 2,   CAIX/CA9↓, 2,   CAIX/CA9↑, 1,   citrate↓, 1,   i-citrate↑, 1,   cMyc↓, 26,   CPT1A↓, 1,   CYP3A4↓, 1,   ECAR↓, 8,   ECAR↝, 1,   ENO1↓, 2,   ERCC1↓, 1,   FASN↓, 7,   FASN↑, 1,   FDG↓, 1,   G6PD↓, 4,   GLS↓, 3,   glucoNG↓, 1,   GlucoseCon↓, 23,   glut↓, 1,   GLUT2↓, 1,   GlutaM↓, 1,   GlutMet↓, 2,   Glycolysis↓, 70,   Glycolysis↑, 1,   GPI↓, 1,   HK2↓, 35,   HMG-CoA↓, 2,   IDH1↑, 1,   lact/pyru↓, 1,   lactateProd↓, 23,   lactateProd↑, 1,   e-lactateProd↓, 1,   LAR↓, 1,   LDH↓, 8,   LDHA↓, 26,   LDL↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   MCU↓, 1,   NADPH↓, 4,   NADPH↑, 1,   PDH↓, 2,   PDH↑, 4,   PDH↝, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 18,   p‑PDK1 / PDPK1↓, 1,   PDK3↓, 1,   PDKs↓, 2,   PFK↓, 6,   PFK1↓, 3,   PFK2?, 1,   PFKFB2↓, 1,   PFKP?, 1,   PFKP↓, 1,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 2,   p‑PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKM2↓, 38,   PKM2:PKM1↓, 1,   POLD1↓, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 5,   PPP↓, 1,   Pyruv↓, 2,   R5P↝, 1,   p‑S6↓, 2,   p‑S6K↓, 2,   SCD1↓, 2,   SHARP↑, 1,   SIRT1↓, 4,   SIRT1↑, 8,   SIRT2↓, 1,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   TPI↓, 1,   Warburg↓, 11,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 76,   Akt↑, 4,   Akt∅, 1,   p‑Akt↓, 27,   APAF1↑, 5,   Apoptosis↓, 5,   Apoptosis↑, 93,   mt-Apoptosis↑, 1,   ASK1↑, 1,   aSmase↝, 1,   BAD↓, 1,   BAD↑, 5,   Bak↑, 5,   BAX↓, 1,   BAX↑, 46,   BAX⇅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 12,   Bcl-2↓, 53,   Bcl-2↑, 2,   Bcl-xL↓, 19,   BID↓, 1,   BID↑, 2,   BIM↓, 1,   BIM↑, 2,   Casp↑, 11,   Casp↝, 1,   Casp∅, 1,   cl‑Casp↑, 1,   Casp1↑, 1,   Casp12?, 1,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 75,   cl‑Casp3↑, 8,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 7,   cl‑Casp7↑, 3,   Casp8↑, 8,   cl‑Casp8↑, 3,   pro‑Casp8↑, 1,   Casp9↑, 41,   cl‑Casp9↑, 5,   cFLIP↓, 5,   Chk2↓, 1,   p‑Chk2↑, 2,   CK2↓, 5,   CSR1↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 39,   Diablo↑, 5,   DR4↑, 3,   DR5↑, 11,   FADD↑, 3,   Fas↓, 1,   Fas↑, 10,   FasL↑, 3,   Ferroptosis↑, 10,   GSDME↑, 1,   HEY1↓, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 7,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 12,   JNK↓, 2,   JNK↑, 9,   p‑JNK↓, 2,   JWA↑, 1,   MAPK↓, 17,   MAPK↑, 3,   MAPK↝, 1,   Mcl-1?, 1,   Mcl-1↓, 18,   Mcl-1↑, 1,   MCT1↓, 2,   MDM2↓, 3,   MDM2↑, 1,   Myc↓, 4,   NAIP↓, 1,   necrosis↑, 2,   NOXA↑, 1,   oncosis↑, 1,   p27/CDKN1B↑, 17,   p38↓, 3,   p38↑, 4,   p‑p38↓, 1,   PUMA↑, 3,   Pyro↑, 1,   RIP1↑, 1,   survivin↓, 25,   Telomerase↓, 15,   TRAIL↑, 2,   TumCD↑, 3,   TUNEL↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 2,   CaMKII ↓, 1,   EF-1α↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 6,   p70S6↓, 2,   p‑p70S6↓, 2,   PAK↓, 1,   SOX9?, 1,   Sp1/3/4↓, 6,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   cJun↑, 1,   EZH2↓, 3,   H3↓, 1,   H3↑, 1,   ac‑H3↑, 3,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 2,   HATs↑, 3,   miR-21↓, 3,   miR-21↑, 1,   miR-27a-3p↓, 1,   miR-30a-5p↑, 1,   other↝, 6,   pRB↑, 1,   p‑pRB↓, 2,   SPP1↓, 1,   tumCV?, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 11,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 17,   GRP78/BiP↓, 1,   GRP78/BiP↑, 8,   Hsc70↓, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 14,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 1,   PERK↑, 4,   UPR↑, 4,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 2,   ATG5↝, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 6,   Beclin-1/ATG6↝, 1,   BNIP3↑, 1,   BNIP3↝, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3B-II↑, 1,   LC3II↓, 1,   LC3II↑, 6,   p62↓, 4,   p62↑, 1,   TumAuto↑, 19,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↝, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   DFF45↓, 1,   DNA-PK↓, 1,   DNAdam↓, 3,   DNAdam↑, 25,   DNArepair↓, 3,   DNArepair↑, 1,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMTs↓, 7,   m-FAM72A↓, 1,   HR↓, 1,   importin α/β↓, 1,   MGMT↓, 1,   p16↑, 3,   P53?, 1,   P53↓, 2,   P53↑, 47,   P53↝, 1,   P53∅, 1,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↓, 1,   PARP↑, 7,   PARP∅, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 29,   PARP1↓, 1,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 16,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   TP53↑, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK1/2/5/9↓, 1,   CDK2↓, 18,   CDK2↑, 1,   CDK4↓, 23,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 11,   cycD1/CCND1↓, 41,   CycD3↓, 1,   cycE/CCNE↓, 8,   cycE/CCNE↑, 2,   cycE1↓, 2,   E2Fs↑, 1,   mitA↑, 1,   P21?, 1,   P21↓, 3,   P21↑, 32,   RB1↑, 1,   p‑RB1↓, 3,   TFAP2A↓, 1,   TumCCA↓, 4,   TumCCA↑, 82,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 3,   p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 1,   AXIN1↑, 1,   CD133↓, 3,   CD24↓, 1,   CD34↓, 1,   CD44↓, 7,   CDK8↓, 1,   CIP2A↓, 1,   cMET↓, 2,   p‑cMET↑, 1,   cMYB↓, 2,   CSCs?, 1,   CSCs↓, 22,   Diff↓, 1,   EIF4E↓, 3,   EMT?, 1,   EMT↓, 47,   EMT↝, 1,   ERK↓, 29,   ERK↑, 1,   ERK↝, 1,   ERK∅, 1,   p‑ERK↓, 9,   p‑ERK↑, 1,   FBXW7↝, 1,   FGF↓, 1,   FGF↑, 1,   FOXM1↓, 2,   FOXO↑, 1,   FOXO3↓, 3,   FOXO3↑, 3,   FOXO4↓, 1,   Gli↓, 1,   Gli1↓, 7,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 5,   HDAC↓, 22,   HDAC1↓, 2,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC8↓, 1,   HH↓, 3,   HRAS↓, 1,   IGF-1↓, 10,   IGF-1R↓, 5,   IGFBP1↑, 1,   IGFBP3↑, 2,   Let-7↑, 1,   MCM2↓, 1,   miR-34a↑, 1,   mTOR↓, 48,   p‑mTOR↓, 10,   mTORC1↓, 6,   p‑mTORC1↓, 1,   n-MYC↓, 1,   Nanog↓, 4,   Nestin↓, 3,   NOTCH↓, 11,   NOTCH1↓, 4,   NOTCH1↑, 1,   NOTCH3↓, 2,   OCT4↓, 4,   P70S6K↓, 3,   p‑P70S6K↓, 2,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFRB↓, 1,   PI3K↓, 62,   PI3K↑, 1,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PTCH1↓, 1,   PTEN↓, 1,   PTEN↑, 22,   RAS↓, 1,   SCF↓, 1,   Shh↓, 6,   Smo↓, 5,   SOX2↓, 4,   Src↓, 1,   STAT↓, 2,   STAT3↓, 52,   p‑STAT3↓, 5,   p‑STAT3↑, 1,   STAT5↓, 1,   TCF↓, 1,   TOP1↓, 5,   TOP2↓, 4,   TRPM7↓, 1,   TumCG?, 1,   TumCG↓, 41,   TumCG↑, 2,   Wnt↓, 13,   Wnt/(β-catenin)↓, 8,  

Migration(tgid=13) ⓘ

5LO↓, 1,   Akt2↓, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 6,   AXL↓, 1,   BACH1↓, 1,   Brk/PTK6↓, 1,   CA↓, 2,   Ca+2↓, 4,   Ca+2↑, 15,   Ca+2↝, 1,   CAFs/TAFs↓, 1,   CAFs/TAFs↝, 1,   cal2↑, 1,   CD11b↓, 1,   CD31/PECAM-1↓, 6,   CDK4/6↓, 1,   CLDN1↓, 1,   CLDN2↓, 1,   CXCL12↓, 3,   E-cadherin↓, 3,   E-cadherin↑, 26,   EphB4↓, 2,   FAK↓, 9,   p‑FAK↓, 3,   Fibronectin↓, 2,   GLI2↓, 2,   GnT-V↝, 1,   heparanase↝, 1,   ITGB1↓, 3,   ITGB1↑, 1,   ITGB3↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   Ki-67↓, 9,   LAMs↓, 2,   MALAT1↓, 3,   MARK4↓, 1,   miR-155↓, 2,   miR-203↓, 1,   miR-203↑, 1,   miR-206↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-29b↓, 1,   miR-384↑, 1,   MMP-10↓, 2,   MMP1↓, 2,   MMP13↓, 3,   MMP2↓, 51,   MMP3↓, 4,   MMP7↓, 5,   MMP9↓, 58,   MMP9:TIMP1↓, 1,   MMPs↓, 23,   MUC4↓, 2,   N-cadherin↓, 17,   NCAM↑, 1,   NM23↑, 1,   PAK1↓, 1,   PDGF↓, 6,   PKA↓, 1,   PKCδ↓, 7,   PKCδ↑, 1,   Rho↑, 1,   RIP3↑, 1,   ROCK1↓, 4,   ROCK1↑, 1,   Slug↓, 4,   SMAD2↓, 2,   p‑SMAD2↓, 1,   SMAD3↓, 4,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 19,   SOX4↓, 1,   talin↓, 1,   TET1↑, 2,   TGF-β↓, 11,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 1,   TIMP2↑, 3,   Treg lymp↓, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 49,   TumCMig↓, 43,   TumCP↓, 74,   TumCP↑, 3,   TumMeta↓, 38,   TumMeta↑, 3,   Twist↓, 10,   uPA↓, 12,   uPAR↓, 1,   VCAM-1↓, 3,   VEGFR1↓, 2,   Vim?, 1,   Vim↓, 24,   Zeb1↓, 7,   ZEB2↓, 1,   ZO-1↑, 1,   α-SMA↓, 2,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 21,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 79,   angioG↑, 1,   ATF4↑, 3,   EGFR↓, 29,   Endoglin↑, 1,   eNOS↓, 2,   FLT4↓, 1,   HIF-1↓, 2,   Hif1a↓, 296,   LOX1↓, 2,   miR-126↑, 1,   miR-210↓, 1,   miR-210↑, 1,   miR-34b-5p↑, 2,   NO↓, 4,   NO↑, 2,   PHDs↑, 1,   TAMS↝, 1,   VEGF↓, 136,   VEGF↑, 2,   VEGFR2/KDR/Flk1↓, 17,   VHL↓, 1,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   CTR1↑, 1,   GLUT1↓, 38,   GLUT1↑, 1,   GLUT3↓, 3,   GLUT3↑, 1,   GLUT4↓, 4,   NHE1↓, 3,   P-gp/ABCB1↓, 6,   P-gp/ABCB1↑, 1,   SVCT-2∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 43,   COX2/PTGS2↑, 3,   CRP↓, 2,   CXCR4↓, 8,   FOXP3↓, 1,   HCAR1↓, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 2,   Igs↑, 1,   IKKα↓, 5,   p‑IKKα↓, 1,   IL1↓, 5,   IL10↓, 5,   IL10↑, 2,   IL12↓, 2,   IL1α↓, 1,   IL1β↓, 9,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 3,   IL4↓, 1,   IL4↑, 1,   IL6↓, 27,   IL8↓, 6,   Imm↑, 2,   Imm↝, 1,   INF-γ↑, 1,   Inflam↓, 11,   JAK↓, 3,   p‑JAK1↓, 1,   JAK2↓, 4,   p‑JAK2↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 76,   NF-kB↑, 2,   p‑NF-kB↓, 1,   NK cell↑, 4,   p50↓, 1,   p65↓, 3,   PD-1↓, 3,   PD-L1↓, 6,   PGE2↓, 9,   PSA↓, 7,   PSA∅, 1,   T-Cell↑, 1,   T-Cell↝, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 3,   TNF-α↓, 13,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   e-pH↑, 1,   i-pH↓, 1,   PLC↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 2,   PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 7,   CDK6↓, 11,   CDK6↑, 1,   CYP19↓, 1,   ER(estro)↓, 2,   GR↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 25,   BioAv↑, 23,   BioAv↝, 5,   BioAv∅, 1,   BioEnh↑, 5,   chemoR↓, 1,   ChemoSen↑, 73,   ChemoSen⇅, 1,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 2,   Dose↓, 3,   Dose↑, 7,   Dose↝, 26,   Dose∅, 9,   eff↓, 15,   eff↑, 96,   eff⇅, 1,   eff↝, 10,   Half-Life↓, 7,   Half-Life↑, 1,   Half-Life↝, 6,   Half-Life∅, 2,   MDR1↓, 4,   P450↓, 4,   RadioS↑, 31,   selectivity↑, 32,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↑, 1,   ALAT↓, 1,   ALAT↝, 1,   ALC∅, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 7,   ascitic↓, 1,   AST↝, 1,   BMPs↑, 1,   BRCA1↓, 1,   BRCA1↝, 1,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 29,   EZH2↓, 3,   FOXM1↓, 2,   GutMicro↑, 3,   HEC1↓, 1,   HER2/EBBR2↓, 6,   hTERT/TERT↓, 7,   IL6↓, 27,   Ki-67↓, 9,   LDH↓, 8,   Myc↓, 4,   NOS2↓, 1,   PD-L1↓, 6,   PSA↓, 7,   PSA∅, 1,   TP53↑, 2,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 26,   AntiCan∅, 2,   AntiTum↑, 7,   cachexia↓, 1,   cardioP↑, 6,   CardioT↓, 1,   chemoP↓, 1,   chemoP↑, 16,   chemoPv↑, 14,   ChemoSideEff↓, 6,   fatigue↓, 2,   hepatoP↑, 6,   IMPDH1↓, 1,   IMPDH2↓, 1,   neuroP↓, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   OS↑, 11,   PRAS40↑, 1,   QoL↑, 3,   radioP↑, 4,   RenoP↑, 2,   Risk↓, 5,   Risk↑, 1,   toxicity↓, 11,   toxicity↝, 5,   toxicity∅, 3,   TumVol↓, 13,   TumW↓, 9,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   CD8+↑, 3,  
Total Targets: 876

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AntiBio↑, 2,   compII↑, 1,   H+/K+-ATPase↓, 1,   IRes↝, 1,   Stroke↓, 4,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 27,   Catalase↑, 14,   Ferroptosis↓, 2,   GPx↑, 10,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 12,   GSR↑, 1,   GSTA1↑, 1,   GSTs↑, 5,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 6,   Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 7,   MDA↓, 8,   MDA↑, 1,   MFN2↑, 1,   MPO↓, 3,   NRF2↑, 18,   RNS↓, 1,   ROS↓, 46,   mt-ROS?, 1,   mt-ROS↑, 1,   SIRT3↑, 1,   SOD↑, 17,   SOD1↑, 2,   SOD2↑, 2,   TBARS↓, 2,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   AIF↓, 1,   ATP↑, 3,   compIII↑, 1,   DRP1/DNM1L↓, 1,   Insulin↑, 2,   MMP↓, 1,   MMP↑, 4,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 4,   AMPK↑, 2,   p‑AMPK↑, 1,   ECAR↓, 1,   glucose↓, 3,   GlucoseCon↑, 1,   H2S↑, 1,   lactateProd↓, 1,   LDH↓, 4,   LDHA↑, 1,   LDL↓, 2,   lipidLev↓, 1,   NADPH↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↑, 2,   PPP↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Akt↑, 2,   Apoptosis↓, 1,   ATF2↑, 1,   BAX↓, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 4,   Casp9↓, 1,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 9,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 3,   p38↓, 2,   Pyro↓, 1,   survivin↓, 1,   TRPV1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 2,   other↑, 4,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 1,   p‑PERK↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   GADD45A↑, 1,   P53↓, 1,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   FOXO3↑, 1,   GSK‐3β↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   IGFBP3↑, 1,   mTOR↓, 1,   PI3K↓, 4,   PI3K↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 1,   APP↓, 1,   Ca+2↓, 1,   MMP2↓, 1,   MMP9↓, 1,   PKCδ↓, 1,   Rho↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TIMP1↓, 1,   TRPC1↓, 1,   TumCI∅, 1,   TumCMig∅, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   ATF4↓, 1,   Hif1a↓, 2,   Hif1a↑, 2,   Hif1a∅, 1,   NO↓, 5,   NO↑, 1,   PDGFR-BB↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   GLUT4↑, 1,   IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 13,   COX2/PTGS2↑, 1,   CRP↓, 1,   CXCR2↑, 1,   CXCR4↓, 1,   IFN-γ↓, 1,   IL10↓, 1,   IL10↑, 2,   IL17↓, 1,   IL18↓, 2,   IL1β↓, 5,   IL4↓, 1,   IL6↓, 9,   IL8↓, 3,   Imm↑, 2,   Inflam↓, 33,   IκB?, 1,   JAK↓, 1,   LPS↓, 1,   pol-M2 MC↑, 1,   NF-kB↓, 14,   NF-kB↑, 1,   PGE2↓, 4,   TLR4↓, 1,   TNF-α↓, 8,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 5,   AChE↑, 1,   BDNF↑, 2,   NGF↑, 1,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 4,   BACE/β-secretase↓, 2,   NLRP3↓, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 23,   BioAv↑, 13,   BioAv↝, 7,   Dose⇅, 1,   Dose↝, 5,   Dose∅, 1,   eff↑, 5,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 4,   Half-Life∅, 3,   P450↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 1,   AST↓, 6,   BG↓, 1,   BP↓, 3,   creat↓, 2,   CRP↓, 1,   GutMicro↑, 5,   IL6↓, 9,   LDH↓, 4,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   AntiCan↓, 1,   AntiCan↑, 5,   AntiDiabetic↑, 7,   antiPs↑, 3,   cardioP↑, 15,   cardioP⇅, 1,   CardioT↓, 1,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↑, 7,   hepatoP↓, 1,   hepatoP↑, 14,   memory↑, 10,   motorD↓, 1,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 27,   Obesity↓, 6,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 5,   toxicity↓, 15,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 5,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 5,   CD8+↑, 1,   Sepsis↓, 1,  
Total Targets: 251

Scientific Paper Hit Count for: Hif1a, HIF1α/HIF1a
14 Sulforaphane (mainly Broccoli)
13 Baicalein
12 Apigenin (mainly Parsley)
12 Resveratrol
10 EGCG (Epigallocatechin Gallate)
9 Berberine
9 Silymarin (Milk Thistle) silibinin
8 Vitamin C (Ascorbic Acid)
8 Metformin
7 Curcumin
7 Honokiol
6 Chrysin
6 Quercetin
6 Shikonin
5 Artemisinin
5 Radiotherapy/Radiation
5 Betulinic acid
5 Propolis -bee glue
5 Phenethyl isothiocyanate
4 Thymoquinone
4 Ashwagandha(Withaferin A)
4 Chlorogenic acid
4 Dichloroacetate
4 Deguelin
4 Ellagic acid
4 Graviola
4 Vitexin
3 Brucea javanica
3 brusatol
3 borneol
3 Boron
3 Capsaicin
3 chaetocin
3 Cinnamon
3 Citric Acid
3 Formononetin
3 Hydrogen Gas
3 Isoliquiritigenin
3 Kaempferol
3 Licochalcone A
3 Licorice
3 Luteolin
3 Magnolol
3 Rosmarinic acid
2 5-fluorouracil
2 Silver-NanoParticles
2 Caffeic acid
2 Carvacrol
2 Emodin
2 Fucoidan
2 Gambogic Acid
2 HydroxyTyrosol
2 Isovitexin
2 Lutein
2 Lycopene
2 Melatonin
2 Proanthocyanidins
2 Sanguinarine
2 Wogonin
1 Coenzyme Q10
1 Annona atemoya Seed Extract
1 Auranofin
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Atorvastatin
1 tamoxifen
1 Baicalin
1 Biochanin A
1 Thymol-Thymus vulgaris
1 Sorafenib (brand name Nexavar)
1 Cannabidiol
1 Celecoxib
1 Celastrol
1 immunotherapy
1 Crocetin
1 Cucurbitacin
1 Bortezomib
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Fenbendazole
1 Fisetin
1 Ai-Tong-An-Gao-Ji
1 Cisplatin
1 flavonoids
1 Gallic acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgolide B
1 γ-linolenic acid (Borage Oil)
1 Hops (Humulus lupulus)
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Ivermectin
1 Juglone
1 Lactobacillus
1 mebendazole
1 metronomic chemo
1 Magnetic Fields
1 Methylsulfonylmethane
1 Niclosamide (Niclocide)
1 Oroxylin-A
1 Oleuropein
1 Oxygen, Hyperbaric
1 doxorubicin
1 Rauwolfia serpentina/Indian Snakeroot
1 salinomycin
1 Gemcitabine (Gemzar)
1 Salvia miltiorrhiza
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Vitamin K2
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:143  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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