LIMK1 Cancer Research Results

LIMK1, LIM domain kinase 1: Click to Expand ⟱
Source:
Type:

LIM domain kinase 1 (LIMK1) is a serine/threonine kinase that regulates actin-cytoskeleton dynamics primarily by phosphorylating and inactivating cofilin. LIMK1 acts downstream of Rho-family GTPases and kinases including ROCK and PAK. In many cancers, LIMK1 expression or activity ↑ promotes actin polymerization, cell migration, invasion, epithelial-mesenchymal transition, and metastatic progression. Conversely, LIMK1 inhibition or activity ↓ commonly reduces cancer-cell motility and invasion. Gene reference.



Scientific Papers found: Click to Expand⟱
8076- KAE,    Kaempferol suppresses prostate cancer metastasis and tumor angiogenesis via disrupting the LIMK1/Cofilin pathway
- in-vivo, Pca, NA
AntiTum↑, TumCP↓, TumCCA↑, VEGF↓, CDK4↓, CDK6↓, LIMK1↓, Cofilin↓, angioG↓,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LIMK1↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   DR5↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   miR-34a↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

Cofilin↓, 1,   E-cadherin↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PD-L1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   Pain↓, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Mucositis↓, 1,   PLA2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GSH↑, 1,   lipid-P↓, 1,   MDA↓, 1,   ROS↓, 2,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↑, 1,   PI3K↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL10↓, 1,   IL4↓, 1,   IL5↓, 1,   Inflam↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   RenoP↑, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 28

Scientific Paper Hit Count for: LIMK1, LIM domain kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1547  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page