IGF-1R Cancer Research Results

IGF-1R, insulin-like growth factor-1 receptor: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Also IGF1R
A link between elevated IGF levels and the development of solid tumors, such as breast, colon, and prostate cancer. Gene amplification of IGF1R, which encodes insulin-like growth factor 1 receptor, is a frequent event across cancer types. Upregulation of IGF1R protein expression in tumor samples and serum in NSCLC patients. Upregulation of IGF-IR signaling can help cancer cells resist anoikis by inhibiting p53 and p21 activation.
Many cancers, including breast, prostate, lung, and colorectal cancers, have been found to exhibit overexpression of IGF-1R. This overexpression can contribute to increased cell proliferation and survival, promoting tumor growth.
Scientific Papers found: Click to Expand⟱
3436- ALA,    Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights Author links open overlay panel
- in-vitro, BC, MCF7
ChemoSen↑, PI3K↓, Akt↓, ATP↓, GlucoseCon↓, ROS↑, PKM2↓, Glycolysis↓, CSCs↓, IGF-1R↓, Furin↓, RadioS↑,
279- ALA,    Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Furin↓, IGF-1R↓, ROS↑, CREB↓, Furin↓, IGF-1R↓,
262- ALA,    Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCP↓, Akt↓, ERK↓, IGF-1R↓, Furin↓, Ki-67↓, AMPK↑, mTOR↓,
3394- ART/DHA,    Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine
IGF-1R↓,
1230- CA,  Caff,    Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - Human, NA, NA
TumVol↓, TumCG↓, ER(estro)↓, cycD1/CCND1↓, IGF-1R↓, p‑Akt↓,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2/PTGS2↓, ROS↑,
5905- CAR,  HCQ,    Synergistic inhibition of metastatic melanoma by carvacrol and chloroquine: an in vitro and in silico investigation of apoptosis and molecular targets
- in-vitro, Melanoma, NA
eff↑, tumCV↑, IGF-1R↓, SIRT2↓, HSP90↓, TumCP↓, Akt↓,
1587- Citrate,    ATP citrate lyase: A central metabolic enzyme in cancer
- Review, NA, NA
ACLY↓, other↓, PFK1↓, ATP↓, PFK2↓, Mcl-1↓, Casp3↑, Casp2↑, Casp9↑, IGF-1R↓, PI3K↓, Akt↓, p‑Akt↓, p‑ERK↓, PTEN↑, Snail↓, E-cadherin↑, ChemoSen↑,
1578- Citrate,    Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
- Review, Var, NA
TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,
1576- Citrate,    Targeting citrate as a novel therapeutic strategy in cancer treatment
- Review, Var, NA
TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, eff↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, eff↑, eff↑, eff↑, eff↑,
1574- Citrate,    Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway
- in-vitro, Lung, A549 - in-vitro, Melanoma, WM983B - in-vivo, NA, NA
TumCG↓, eff↑, T-Cell↑, p‑IGF-1R↓, p‑Akt↓, PTEN↑, p‑eIF2α↑, OCR↓, ROS↓, ECAR∅, IL1↑, TNF-α↑, IL10↑, IGF-1R↓, eIF2α↑, PTEN↑, TCA↓, Glycolysis↓, selectivity↑, *toxicity∅, Dose∅,
8295- lign,    Distribution, biosynthesis and therapeutic potential of lignans
- Review, Var, NA
*Ingr?, *BioAv↝, *antiOx↑, *AntiCan↑, *Inflam↓, *other?, Dose↝, AntiTum↑, pS2/TFF1↓, Bcl-2↓, IGF-1R↓, *radioP↑, *HO-1↑, GSTM1↑, NQO1↑, ChemoSen↑, *AntiDiabetic↑, *glucose↓, *GSH↑, *SOD↑, *MDA↓, *NO↓, *Bacteria↓, *AntiFungal↑,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
8393- LT,    Progress, pharmacokinetics and future perspectives of luteolin modulating signaling pathways to exert anticancer effects: A review
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, EMT↓, Imm↝, ChemoSen↑, *Inflam↓, *COX2/PTGS2↓, *NF-kB↓, MMP2↓, MMP9↓, p‑Akt↓, p‑PI3K↓, IGF-2↓, IGF-1R↓, CXCL16↓, NOTCH1↓, HES1↓, VEGF↓, ROS↑,
3262- Lyco,    Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1
- in-vitro, adrenal, SK-HEP-1
TumCI↓, MMP9↓, NF-kB↓, Sp1/3/4↓, IGF-1R↓, i-ROS↓,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
1203- MSM,    Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways
- vitro+vivo, BC, MDA-MB-231
tumCV↓, STAT3↓, STAT5↓, IGF-1↓, Hif1a↓, VEGF↓, Brk/PTK6↓, IGF-1R↓,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
86- QC,  PacT,    Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3)
- vitro+vivo, Pca, PC3
BAD↑, IGFBP3↑, Cyt‑c↑, cl‑Casp9↑, Casp10↑, cl‑PARP↑, Casp3↑, IGF-1R↓, PI3K↓, p‑Akt↓, cycD1/CCND1↓, IGF-1↓, IGF-2↓, IGF-1R↓, MMP↓, Apoptosis↑, NA?,
79- QC,    Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats
- in-vivo, Pca, NA
GSH↑, SOD↑, Catalase↑, GPx↑, GSR↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, lipid-P↓, H2O2↓, Raf↓, p‑MEK↓, Bcl-2↑, Bcl-xL↑, Casp3↑, Casp8↑, Casp9↑,
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↑, Fas↓, Hsc70↓, Hif1a↓, Mcl-1↓, HSP90↓, FLT4↓, EphB4↓, DNA-PK↓, PARP1↓, ATM↓, XIAP↝, PLC↓, GnT-V↝, heparanase↝, NM23↑, CSR1↑, SPP1↓, DNMT1↓, HDAC4↓, CXCR4↓, β-catenin/ZEB1↓, FBXW7↝, AMACR↓, cycD1/CCND1↓, IGF-1R↓, IMPDH1↓, IMPDH2↓, HEC1↓, NHE1↓, NOS2↓,
2981- RES,    Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways
- in-vitro, Colon, HT-29 - in-vitro, Colon, SW48
TumCCA↑, p27/CDKN1B↑, cycD1/CCND1↓, TumCP↓, IGF-1R↓, Akt↓, Wnt↓, P53↑, Apoptosis↑, Sp1/3/4↓, cl‑PARP↑, β-catenin/ZEB1↓, MDM2↓,

Showing Research Papers: 1 to 22 of 22

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 22

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CXCL16↓, 1,   GSTM1↑, 1,   HES1↓, 1,   miR-107↑, 1,   miR-224↓, 1,   miR-422a↑, 1,   MMP16↓, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 2,   GPx↑, 1,   GSH↑, 2,   GSR↑, 1,   H2O2↓, 1,   lipid-P↓, 2,   NQO1↑, 1,   ROS↓, 2,   ROS↑, 4,   ROS⇅, 1,   i-ROS↓, 1,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   p‑MEK↓, 1,   MMP↓, 1,   OCR↓, 1,   Raf↓, 1,   SDH↓, 1,   XIAP↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 2,   ALAT↝, 1,   AMACR↓, 1,   AMPK↑, 1,   CAIX/CA9↑, 1,   citrate↓, 1,   CPT1A↓, 1,   CREB↓, 1,   ECAR∅, 1,   FASN↑, 2,   FBPase↑, 1,   glucoNG↑, 1,   GlucoseCon↓, 1,   Glycolysis↓, 4,   HK2↓, 1,   PDH↓, 1,   PFK1↓, 2,   PFK2?, 1,   PFK2↓, 2,   PKM2↓, 2,   SIRT2↓, 1,   TCA↓, 2,   TCA↑, 1,   Warburg↓, 1,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 11,   p‑Akt↓, 5,   Apoptosis↑, 4,   aSmase↝, 1,   BAD↑, 1,   BAX↑, 3,   Bcl-2↓, 2,   Bcl-2↑, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   BID↑, 1,   Casp10↑, 1,   Casp2↑, 3,   Casp3↑, 7,   Casp7↑, 1,   Casp8↑, 3,   Casp9↑, 6,   cl‑Casp9↑, 1,   CSR1↑, 1,   Cyt‑c↑, 1,   Diablo↑, 1,   Fas↓, 1,   hTERT/TERT↓, 1,   iNOS↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 4,   MDM2↓, 1,   p27/CDKN1B↑, 2,   pS2/TFF1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,   other↓, 1,   SPP1↓, 1,   tumCV↓, 2,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↑, 1,   p‑eIF2α↑, 1,   Hsc70↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 3,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   DNA-PK↓, 1,   DNArepair↑, 1,   DNMT1↓, 1,   P53↑, 3,   cl‑PARP↑, 3,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 6,   P21↑, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 1,   ERK↓, 2,   p‑ERK↓, 1,   FBXW7↝, 1,   HDAC4↓, 1,   IGF-1↓, 2,   IGF-1R↓, 24,   p‑IGF-1R↓, 1,   IGF-2↓, 2,   IGFBP3↑, 1,   miR-34a↑, 1,   mTOR↓, 3,   NOTCH↓, 1,   NOTCH1↓, 1,   PI3K↓, 6,   p‑PI3K↓, 1,   PTEN↑, 6,   STAT3↓, 4,   STAT5↓, 1,   TumCG↓, 2,   TumCG↑, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Brk/PTK6↓, 1,   Ca+2↓, 1,   E-cadherin↑, 2,   EphB4↓, 1,   Furin↓, 4,   GnT-V↝, 1,   heparanase↝, 1,   Ki-67↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-340↓, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP3↓, 1,   MMP9↓, 5,   NM23↑, 1,   Snail↓, 2,   Treg lymp↓, 1,   TumCI↓, 2,   TumCP↓, 9,   TumMeta↓, 2,   TumMeta↑, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   FLT4↓, 1,   Hif1a↓, 5,   NO↓, 1,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT1↑, 1,   GLUT3↑, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 2,   CXCR4↓, 1,   FOXP3↓, 1,   IL1↑, 1,   IL10↑, 1,   IL6↓, 3,   IL8↓, 1,   Imm↝, 1,   NF-kB↓, 4,   NK cell↑, 1,   T-Cell↑, 2,   T-Cell↝, 1,   Th1 response↑, 1,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

PLC↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   ER(estro)↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 6,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 1,   Dose∅, 4,   eff↓, 1,   eff↑, 9,   RadioS↑, 2,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↝, 1,   ALP↝, 1,   AR↓, 3,   AST↝, 1,   HEC1↓, 1,   hTERT/TERT↓, 1,   IL6↓, 3,   Ki-67↓, 1,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   ChemoSideEff↓, 1,   IMPDH1↓, 1,   IMPDH2↓, 1,   OS↑, 1,   radioP↑, 1,   TumVol↓, 1,   TumVol∅, 1,   TumW∅, 1,  
Total Targets: 212

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Ingr?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 3,   H2O2↓, 1,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 2,   ROS↓, 2,   SOD↑, 3,   SOD2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IKKα↓, 1,   Inflam↓, 2,   NF-kB↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   radioP↑, 1,   toxicity↓, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,  
Total Targets: 37

Scientific Paper Hit Count for: IGF-1R, insulin-like growth factor-1 receptor
4 Citric Acid
4 Quercetin
3 Alpha-Lipoic-Acid
2 Caffeic acid
2 Luteolin
1 Artemisinin
1 Caffeine
1 Carvacrol
1 hydroxychloroquine
1 SDG/lignans
1 Lycopene
1 Melatonin
1 Methylsulfonylmethane
1 Paclitaxel/Taxol
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:155  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page