IL6 Cancer Research Results

IL6, Interleukin-6: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Interleukin-6 (IL-6) is a cytokine that plays a significant role in inflammation and the immune response. It is produced by various cell types, including T cells, B cells, macrophages, and fibroblasts.
IL-6 can promote tumor cell proliferation and survival. Many cancer cells produce IL-6, which can create an autocrine loop that supports their growth.
IL-6 is a high-value inflammatory biomarker in cancer, reporting cytokine burden, catabolic stress, and STAT3-linked survival signaling. While not tumor-specific, elevated and rising IL-6 strongly predicts poor prognosis and limited treatment tolerance, making it an important system-state indicator alongside CRP and ferritin.


Scientific Papers found: Click to Expand⟱
2326- 2DG,    Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2–Signal Transducer and Activator of Transcription 3 Pathway
- in-vivo, Nor, NA
PKM2↓, Inflam↓, TNF-α↓, IL6↓, OS↑,
5463- AF,    Will Auranofin Become a Golden New Treatment Against COVID-19?
- Review, Covid, NA
IL6↓, NF-kB↓, ATF2↓, TrxR↓, ROS↑, Apoptosis↑, IL6↓, Dose↑,
5444- AG,    A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine
- Review, Var, NA
*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,
4387- AgNPs,    Attenuation of diethylnitrosamine (DEN) - Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles
- in-vitro, Liver, NA
IL6↓, TNF-α↓, IL1β↓, hepatoP↑,
4363- AgNPs,    Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma
- in-vivo, fibroS, NA
TumVol↓, TNF-α↓, IL6↓, IL1β↓, *toxicity↝, TumCG↓, selectivity↑, selectivity↑, Weight↑, ROS↑, NO↑,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2/PTGS2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, NA, NA
NRF2↑, COX2/PTGS2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
7907- Api,  IVT,    Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells
- Review, Var, NA
ChemoSen↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, MMP↓, TumMeta↓, MAPK↓, VEGF↓, MMP9↓, TGF-β↓, Inflam↓, COX2/PTGS2↓, IL6↓, NF-kB↓, TumCCA↑, P53↑, cycD1/CCND1↓, BAX↑, Casp↓, Bcl-2↓, CD133↓, Nanog↓, SOX2↓, Akt↓, TumCP↓, TumCMig↓, YAP/TEAD↓, CCN2/CTGF↓, CCN1/CYR61↓, SIRT3↓, SIRT6↓, PCNA↓, DNMT1↓, miR-34a↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
1543- Api,    Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms
- Review, NA, NA
TNF-α↓, IL1β↓, IL6↓, IL10↓, COX2/PTGS2↓, iNOS↓, Inflam↓, Dose∅, Dose∅,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, VEGFR2/KDR/Flk1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27/CDKN1B↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
565- ART/DHA,    Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma
STAT↓, IL6↓, pro‑Casp3↝, Bcl-xL↝, survivin↝,
5396- Ash,    Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
- Review, Var, NA
selectivity↑, ROS↑, Apoptosis↑, ChemoSen↑, RadioS↑, NF-kB↓, ER-α36↓, P53↑, *ROS∅, γH2AX↑, DNAdam↑, MMP↓, XIAP↓, IAP1↓, survivin↓, SOD↓, Dose↝, IL6↓, TNF-α↓, COX2/PTGS2↓, p‑Akt↓, NOTCH1↓, FOXO↑, Casp↑, MMP2↓, CSCs↓, *ROS↓, *SOD2↑, chemoP↑, ChemoSen↑, RadioS↑,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
1177- Ash,    Withaferin A downregulates COX-2/NF-κB signaling and modulates MMP-2/9 in experimental endometriosis
- in-vivo, EC, NA
TumVol↓, MMP2↓, MMP9↓, NF-kB↓, COX2/PTGS2↓, NO↓, IL1β↓, IL6↓,
5384- AsP,  MEL,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
1146- AsP,    Potential use of nanoformulated ascorbyl palmitate as a promising anticancer agent: First comparative assessment between nano and free forms
- in-vivo, Nor, NA
TumCCA↑, Apoptosis↑, IL6↓, STAT3↓, angioG↓, TumMeta↓, VEGF↓, MMP9↓, SOD↑, Catalase↑, GSH↓, MDA↓, NO↓, *BioAv↑,
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,
5568- B-Gluc,  immuno,    Beta-glucans in oncology: revolutionizing treatment with immune power & tumor targeting
- Review, Var, NA
TNF-α↓, IL6↓, NF-kB↓, PD-L1↓, Imm↑, BAX↑, Bcl-2↓, TumCCA↑, angioG↓, VEGF↓, MMPs↓, OS↑, chemoP↑, eff↑, BioAv↑,
5577- B-Gluc,    Lentinan progress in inflammatory diseases and tumor diseases
- Review, Var, NA - Review, IBD, NA
AntiTum↑, GutMicro↑, *Inflam↓, *TNF-α↓, *NF-kB↓, ChemoSen↑, OS↑, Imm↑, IL6↓, ERK↓, MAPK↓, *antiOx↑, eff↑,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2/KDR/Flk1↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
5553- BBM,    A review on berbamine–a potential anticancer drug
- Review, Var, NA
P-gp/ABCB1↓, MDR1↓, survivin↓, NF-kB↓, TumCP↓, TumCCA↑, Apoptosis↑, SMAD3↑, P21↑, cycD1/CCND1↓, cMyc↑, Bcl-2↓, Bcl-xL↓, BAX↑, CaMKII ↓, ChemoSen↑, MMP2↓, MMP9↓, TIMP1↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, cl‑PARP↑, IL6↓, ROS↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
1092- BBR,    Berberine as a Potential Anticancer Agent: A Comprehensive Review
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumAuto↑, TumCI↓, IL1↓, IL6↓, TNF-α↓, LDH↓, P2X7↓, proCasp1↓, Casp1↓, ASC↓,
6499- BCP,    JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation
- in-vitro, OS, MG63
ROS↑, Apoptosis↑, TumCP↓, BAX↑, Casp3↑, Bcl-2↓, MMP↓, DNAdam↑, TNF-α↓, COX2/PTGS2↓, NF-kB↓, IL6↓, Inflam↓, JAK1↑, STAT3↑,
6501- BCP,    β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study
- in-vitro, Oral, KB
TumCG↓, Apoptosis↑, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, ROS↑, MMP↓, DNAdam↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, PCNA↓, cycD1/CCND1↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, IL6↓, VEGF↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp/ABCB1↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
5653- BNL,    Borneol hinders the proliferation and induces apoptosis through the suppression of reactive oxygen species-mediated JAK1 and STAT-3 signaling in human prostate cancer cells
- in-vitro, Pca, PC3
ROS↑, TumCP↓, cycD1/CCND1↓, cycE1↓, Apoptosis↑, BAX↓, Casp3↑, Bcl-2↓, IL6↓, JAK1↓, STAT3↓,
743- Bor,    Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms
- in-vitro, CRC, NA
BAX↑, Bcl-2↓, GPx↑, SOD↑, Catalase↑, MDA↓, TNF-α↓, IL6↓, IL10↑,
726- Bor,    Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
- Review, NA, NA
NAD↝, SAM-e↝, PSA↓, IGF-1↓, Cyc↓, P21↓, p‑MEK↓, p‑ERK↓, ROS↑, SOD↓, Catalase↓, MDA↑, GSH↓, IL1↓, IL6↓, TNF-α↓, BRAF↝, MAPK↝, PTEN↝, PI3K/Akt↝, eIF2α↑, ATF4↑, ATF6↑, NRF2↑, BAX↑, BID↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2/PTGS2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
5740- Buty,    A Review of Nutritional Regulation of Intestinal Butyrate Synthesis: Interactions Between Dietary Polysaccharides and Proteins
- Review, RCC, NA
*eff↓, Dose↝, eff↑, HDAC↓, ac‑H3↓, ac‑H4↓, *HCAR2↑, *Inflam↓, *ROS↓, *NRF2↑, *GSH↑, *CLDN1↑, *ZO-1↑, IL1β↓, IL6↓, COX2/PTGS2↓, eff↝, eff↑, other↝,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2/PTGS2↓, ROS↑,
1011- CA,    Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways
- in-vivo, NA, NA
iNOS↓, IL6↓, SOX9↑, NF-kB↓, MAPK↓,
5746- CA,    Caffeic acid hinders the proliferation and migration through inhibition of IL-6 mediated JAK-STAT-3 signaling axis in human prostate cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
tumCV↓, ROS↑, TumCCA↑, Apoptosis↑, p‑MAPK↓, ERK↓, JNK↓, p38↓, IL6↓, JAK1↓, p‑STAT3↓, cycD1/CCND1↓, CDK1↓, BAX↑, Casp3↑, Bcl-2↓, TumCD↑,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
5939- Cela,  Chemo,    Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
- in-vitro, Melanoma, U266 - in-vitro, Melanoma, RPMI-8226
TumCP↓, ChemoSen↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, XIAP↓, Mcl-1↓, NF-kB↓, IL6↓, STAT3↓, Apoptosis↑, TumCCA↑, Casp3↑, HSP90↓, HO-1↑, JAK2↓, Src↓, Akt↑,
5942- Cela,    Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer
- vitro+vivo, NSCLC, H460 - in-vitro, NSCLC, PC9
TumCG↓, TumCP↓, TumMeta↓, ROS↑, ER Stress↑, p‑STAT3↓, Apoptosis↑, eff↓, TumCG↓, IL6↓, other↝,
5946- Cela,    The anti-cancer mechanism of Celastrol by targeting JAK2/STAT3 signaling pathway in gastric and ovarian cancer
- in-vitro, Var, NA
toxicity⇅, toxicity↓, TumCG↓, ROS↑, IL6↓, JAK2↓, STAT3↓,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP/DDIT3↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
2393- Cela,    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- in-vivo, Sepsis, NA - in-vitro, Nor, RAW264.7
OS↑, PKM2↓, Glycolysis↓, Warburg↓, Inflam↓, HMGB1↓, ALAT↓, AST↓, TNF-α↓, IL1β↓, IL6↓,
2392- Cela,    The role of natural products targeting macrophage polarization in sepsis-induced lung injury
- Review, Sepsis, NA
TNF-α↓, IL1β↓, IL6↓, Warburg↓, PKM2↓, NRF2↑, HO-1↑, NF-kB↓, iNOS↓, M1↓,
6641- Cen,    Asiaticoside Increases Caspase-9 Activity in MCF-7 Cells and Inhibits TNF-α and IL-6 Expression in Nude Mouse Xenografts via the NF-κB Pathway
- in-vitro, BC, MCF7
Casp9↑, TNF-α↓, IL6↓, NF-kB↓, TumCG↓, Inflam↓, TumCP↓, EMT↓,
6017- CGA,    Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
- Review, Var, NA
AntiCan↑, *chemoP↑, TNF-α↓, COX2/PTGS2↓, IL6↓, eff↑, PD-L1↓, *cognitive↓, *Aβ↓, *TAC↑, *SOD↑, *eff↑, *eff↑, ChemoSen↑, tumCV↓, Apoptosis↑, ERK↓, chemoP↑, *GPx↑, *GSTs↑, *GSH↑, *SOD↑, *Catalase↑, *ROS↓, *lipid-P↓, *MDA↓, *Casp3↓, *HO-1↓, cardioP↑, radioP↑,
6007- CGA,    A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer
- Review, CRC, NA
antiOx↑, TumCCA↑, Apoptosis↑, Wnt↝, PI3K↝, MAPK↝, ROS↓, BioAv↝, P53↑, P21↑, CDK1↑, Ki-67↓, Ca+2↑, p‑Akt↓, mTOR↓, GSH↑, NRF2↑, HO-1↑, COX2/PTGS2↓, TNF-α↓, IL1β↓, IL6↓,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,

Showing Research Papers: 1 to 50 of 160
Page 1 of 4 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 160

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↓, 1,   CCN1/CYR61↓, 1,   CTSK↓, 1,   CUL1↝, 1,   CUL5↝, 1,   CX43/GJA1↓, 1,   ERCC4/XPF↓, 1,   HLA-I/II↑, 1,   IL13↓, 1,   Ku70/XRCC6↓, 1,   miR-107↑, 1,   miR-134↑, 1,   miR-224↓, 1,   miR-422a↑, 1,   MMP16↓, 1,   MTA1↓, 1,   NA↓, 1,   NA↑, 1,   NLR↓, 1,   PLA2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   ARE↓, 1,   Catalase↓, 5,   Catalase↑, 5,   Ceru↓, 1,   CYP1A1↓, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GPx↑, 6,   GSH↓, 13,   GSH↑, 6,   GSR↓, 2,   GSR↑, 1,   GSTA1↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 2,   HO-1↓, 2,   HO-1↑, 11,   Keap1↓, 1,   lipid-P↑, 3,   MDA↓, 4,   MDA↑, 2,   MPO↓, 3,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 6,   NRF2↑, 14,   p‑NRF2↓, 1,   OXPHOS↓, 2,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   ROS?, 1,   ROS↓, 14,   ROS↑, 63,   ROS⇅, 4,   i-ROS↑, 1,   SAM-e↝, 1,   SIRT3↓, 1,   SOD↓, 9,   SOD↑, 9,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TAC↓, 1,   TBARS↑, 1,   Trx1↓, 1,   Trx1↑, 1,   TrxR↓, 4,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 4,   ATP↑, 1,   CDC2↓, 2,   CDC25↓, 3,   EGF↓, 1,   ETC↓, 1,   FGFR1↓, 1,   MEK↓, 1,   p‑MEK↓, 1,   MMP↓, 31,   MMP↑, 1,   MMP↝, 1,   MPT↑, 1,   mtDam↑, 8,   OCR↓, 1,   Raf↓, 2,   XIAP?, 1,   XIAP↓, 12,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ACC↑, 1,   ACLY↓, 1,   ALAT↓, 5,   ALAT↝, 1,   AMPK↑, 7,   p‑AMPK↑, 1,   ATG7↑, 1,   CAIX/CA9↑, 1,   cMyc↓, 22,   cMyc↑, 1,   ECAR↓, 1,   ERCC1↓, 1,   FASN↓, 3,   GlucoseCon↓, 4,   Glycolysis↓, 13,   Histones↝, 1,   HK2↓, 9,   HMG-CoA↓, 1,   IR↓, 1,   lactateProd↓, 5,   LDH↓, 5,   LDH↑, 2,   i-LDH↓, 1,   LDHA↓, 3,   LDL↓, 1,   NAD↝, 1,   NADPH↑, 2,   PDK1 / PDPK1↓, 2,   PFK↓, 2,   PI3K/Akt↓, 2,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 8,   p‑PKM2↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 6,   p‑S6↓, 1,   p‑S6K↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 3,   SIRT2↓, 1,   STK11/LKB1↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

Akt↓, 42,   Akt↑, 2,   p‑Akt↓, 13,   APAF1↑, 2,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 50,   ASK1↑, 1,   ATF2↓, 1,   BAD↑, 2,   Bak↑, 2,   BAX↓, 2,   BAX↑, 36,   Bax:Bcl2↑, 5,   Bcl-2↓, 43,   Bcl-2↑, 1,   Bcl-xL↓, 13,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 3,   BIM↑, 1,   Casp↓, 2,   Casp↑, 5,   Casp1↓, 2,   proCasp1↓, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 54,   cl‑Casp3↑, 3,   pro‑Casp3↝, 1,   Casp7↑, 5,   Casp8↑, 10,   cl‑Casp8↑, 1,   Casp9↑, 30,   cl‑Casp9↑, 2,   proCasp9↓, 1,   cFLIP↓, 3,   Chk2↓, 1,   p‑Chk2↑, 1,   CK2↓, 1,   Cyt‑c↑, 21,   Diablo↑, 2,   DR5↑, 7,   Fas↓, 2,   Fas↑, 7,   FasL↓, 1,   FasL↑, 3,   Ferroptosis↑, 1,   GSDMD↑, 1,   HEY1↓, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 7,   IAP1↓, 5,   iNOS↓, 19,   JNK↓, 4,   JNK↑, 4,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAPK↓, 15,   MAPK↑, 5,   MAPK↝, 3,   p‑MAPK↓, 1,   Mcl-1↓, 8,   MDM2↓, 5,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↑, 1,   Myc↓, 1,   NOXA↑, 1,   oncosis↑, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 8,   P2X7↓, 1,   p38↓, 4,   p38↑, 4,   p‑p38↓, 2,   p‑p38↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 17,   survivin↝, 1,   Telomerase↓, 3,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↑, 4,   TumCD∅, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,   cSrc↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   PAK↓, 1,   SOX9?, 1,   SOX9↑, 1,   Sp1/3/4↓, 6,  

Transcription & Epigenetics(tgid=7) ⓘ

BowelM↑, 2,   ChrMod↑, 1,   cJun↓, 2,   p‑cJun↓, 1,   EZH2↓, 2,   H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 3,   H4↓, 1,   ac‑H4↓, 1,   ac‑H4↑, 3,   HATs↓, 3,   miR-21↓, 3,   miR-21↑, 1,   miR-27a-3p↓, 1,   other↓, 2,   other↝, 3,   p‑pRB↓, 1,   tumCV↓, 14,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 7,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 4,   ER Stress↑, 8,   GRP78/BiP↑, 3,   HSP27↓, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 6,   HSPs↑, 1,   PERK↑, 1,   UPR↑, 2,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 3,   BNIP3↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3II↓, 1,   LC3II↑, 4,   TumAuto↑, 11,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↑, 1,   BRCA2↑, 1,   CHK1↓, 1,   p‑CHK1↑, 1,   CYP1B1↑, 1,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 18,   DNArepair↓, 2,   DNArepair↑, 1,   DNMT1↓, 5,   DNMT3A↓, 1,   DNMTs↓, 3,   HR↓, 1,   p16↑, 3,   P53?, 1,   P53↓, 1,   P53↑, 29,   P53↝, 1,   p‑P53↓, 1,   i-P53↓, 1,   p53 Wildtype↑, 1,   PARP↓, 2,   PARP↑, 4,   cl‑PARP↓, 1,   cl‑PARP↑, 19,   PARP1↑, 1,   PCNA↓, 13,   RAD51↓, 1,   SIRT6↓, 1,   TP53↑, 3,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 10,   CDK2↑, 1,   CDK4↓, 16,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 34,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 5,   cycE1↓, 2,   E2Fs↓, 3,   P21↓, 3,   P21↑, 14,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 51,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   BRAF↝, 1,   CD133↓, 2,   CD133↑, 1,   CD34↓, 1,   CD44↓, 4,   CDK8↓, 1,   cFos↓, 4,   cFos↑, 1,   cMET↓, 3,   cMYB↓, 1,   CSCs↓, 19,   Diff↓, 1,   EMT↓, 26,   EMT↑, 1,   EP2↓, 1,   EpCAM↓, 1,   ERK↓, 21,   ERK↑, 3,   ERK↝, 1,   p‑ERK↓, 7,   FGF↓, 2,   FOXM1↓, 1,   FOXO↑, 2,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 2,   p‑FOXO3↓, 1,   Gli↓, 1,   Gli1↓, 4,   GSK‐3β↓, 5,   HDAC↓, 8,   HDAC1↓, 2,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC4↓, 1,   HH↓, 2,   HH↝, 1,   IGF-1↓, 6,   IGF-1R↓, 3,   IGFBP3↑, 2,   Let-7↑, 2,   LRP6↓, 1,   miR-34a↑, 3,   mTOR↓, 24,   p‑mTOR↓, 3,   mTORC1↓, 1,   p‑mTORC1↓, 1,   n-MYC↓, 1,   Nanog↓, 4,   Nestin↓, 2,   NOTCH↓, 10,   NOTCH↝, 1,   NOTCH1↓, 10,   NOTCH1↑, 2,   NOTCH3↓, 2,   OCT4↓, 4,   P70S6K↓, 3,   p‑P70S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 31,   PI3K↝, 1,   p‑PI3K↓, 1,   PTCH1↓, 1,   PTEN↓, 1,   PTEN↑, 12,   PTEN↝, 1,   RAS↓, 6,   Shh↓, 8,   SHP1↑, 2,   Smo↓, 1,   SOX2↓, 6,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 3,   STAT1↓, 2,   STAT3↓, 48,   STAT3↑, 1,   p‑STAT3↓, 13,   i-STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 2,   STAT6↓, 1,   p‑STAT6↓, 1,   TCF↓, 1,   TOP1↓, 1,   TOP2↓, 3,   TOP2↑, 1,   TumCG↓, 20,   TumCG↑, 1,   Wnt↓, 14,   Wnt↝, 2,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

5LO↓, 3,   AntiAg↓, 1,   AP-1↓, 4,   ATPase↓, 1,   AXL↓, 1,   Ca+2↑, 7,   Ca+2↝, 1,   CAFs/TAFs↓, 1,   CCN2/CTGF↓, 2,   CD31/PECAM-1↓, 1,   Cdc42↓, 1,   CDK4/6↓, 1,   CEA↓, 2,   CLDN1↓, 2,   CLDN2↓, 1,   COL1↓, 1,   COL3A1↓, 1,   CXCL12↓, 3,   DLC1↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 19,   ER-α36↓, 1,   FAK↓, 7,   FAK↝, 1,   Fibronectin↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB1↑, 1,   Ki-67↓, 7,   LAMs↓, 1,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   miR-139-5p↑, 1,   miR-155↓, 2,   miR-340↓, 1,   MMP-10↓, 2,   MMP1↓, 4,   MMP13↓, 2,   MMP2↓, 44,   MMP3↓, 3,   MMP7↓, 7,   MMP9↓, 48,   MMP9:TIMP1↓, 1,   MMPs↓, 10,   N-cadherin↓, 13,   NCAM↑, 1,   PAK1↓, 1,   PDGF↓, 2,   PKA↓, 2,   PKCδ↓, 2,   Rac1↓, 1,   RAGE↓, 1,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 2,   Slug↓, 7,   p‑SMAD2↓, 1,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail↓, 17,   SOX4↑, 1,   TET1↑, 2,   TGF-β↓, 13,   TGF-β1↓, 1,   TIMP1↓, 2,   TIMP1↑, 2,   TIMP2↓, 2,   TIMP2↑, 3,   Treg lymp↓, 1,   TSP-1↑, 3,   TumCA↓, 1,   TumCI↓, 24,   TumCMig↓, 16,   TumCP↓, 41,   TumCP↑, 1,   TumMeta↓, 31,   TumMeta↑, 2,   Twist↓, 10,   Tyro3↓, 1,   uPA↓, 6,   uPA↝, 1,   uPAR↓, 2,   VCAM-1↓, 1,   Vim↓, 17,   Vim↑, 1,   Zeb1↓, 5,   ZEB2↓, 1,   ZO-1↑, 2,   α-SMA↓, 4,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 19,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 31,   ATF4↑, 3,   ATF4↝, 1,   EGFR↓, 12,   EGFR↑, 1,   p‑EGFR↓, 2,   EPR↑, 1,   HIF-1↓, 3,   Hif1a↓, 27,   NO↓, 9,   NO↑, 1,   VEGF↓, 53,   VEGFR2/KDR/Flk1↓, 9,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 3,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   P-gp/ABCB1↓, 6,   P-gp/ABCB1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 2,   CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 3,   COX1↓, 1,   COX2/PTGS2↓, 67,   COX2/PTGS2↑, 2,   CRP↓, 7,   CXCc↓, 1,   CXCL1↓, 1,   CXCR4↓, 11,   CXCR4↑, 1,   DCells↑, 2,   FOXP3↓, 1,   GM-CSF↓, 3,   HMGB1↓, 4,   ICAM-1↓, 4,   IFN-γ↓, 5,   IFN-γ↑, 1,   IKKα↓, 5,   p‑IKKα↓, 2,   IL1↓, 13,   IL1↑, 1,   IL10↓, 11,   IL10↑, 4,   IL12↓, 6,   IL12↑, 1,   IL17↓, 2,   IL18↓, 3,   IL1α↓, 1,   IL1β↓, 44,   IL2↓, 5,   IL2↑, 4,   IL22↓, 2,   IL23↓, 1,   IL4↓, 3,   IL4↑, 2,   IL5↓, 1,   IL6↓, 161,   IL8↓, 22,   IL8↑, 1,   Imm↑, 4,   Imm↝, 1,   INF-γ↓, 1,   Inflam↓, 36,   IRAK4↓, 1,   IκB↑, 1,   JAK↓, 3,   JAK1?, 1,   JAK1↓, 7,   JAK1↑, 1,   p‑JAK1↓, 1,   JAK2↓, 11,   p‑JAK2↓, 1,   M1↓, 1,   Macrophages↑, 1,   MCP1/CCL2↓, 6,   MDSCs↓, 1,   MIP2↓, 2,   MyD88↓, 1,   NF-kB↓, 81,   p‑NF-kB↓, 2,   NK cell↑, 3,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 1,   PD-L1↓, 6,   PGE1↓, 1,   PGE2↓, 14,   PSA↓, 3,   PSA∅, 1,   RANTES?, 1,   Resistin↓, 1,   T-Cell↑, 1,   Th1 response?, 1,   Th1 response↑, 1,   TLR4↓, 8,   TNF-α↓, 74,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 5,   NLRP3↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   CDK6↓, 9,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 16,   BioAv↑, 16,   BioAv↝, 4,   BioEnh↑, 2,   ChemoSen↑, 37,   ChemoSen⇅, 1,   ChemoSen↝, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 6,   Dose↝, 19,   Dose∅, 5,   eff↓, 5,   eff↑, 57,   eff↝, 4,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 5,   MDR1↓, 3,   MRP1/ABCC1↓, 2,   P450↓, 2,   RadioS↑, 18,   selectivity↑, 14,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 5,   AST↓, 3,   AST↝, 1,   BMD↑, 1,   BRAF↝, 1,   BRCA1↑, 1,   CA125↓, 1,   CEA↓, 2,   CRP↓, 7,   CYFRA21-1↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 12,   EGFR↑, 1,   p‑EGFR↓, 2,   ERα/ESR1↓, 1,   EZH2↓, 2,   FOXM1↓, 1,   GutMicro↑, 3,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 7,   IL6↓, 161,   Ki-67↓, 7,   LDH↓, 5,   LDH↑, 2,   i-LDH↓, 1,   Myc↓, 1,   NOS2↓, 2,   NSE↓, 1,   PD-L1↓, 6,   PSA↓, 3,   PSA∅, 1,   RAGE↓, 1,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 16,   antiNeop↑, 1,   AntiTum↑, 6,   AntiTum∅, 1,   Appetite↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 6,   CardioT↑, 1,   chemoP↑, 13,   chemoPv↑, 3,   ChemoSideEff↓, 2,   hepatoP↓, 1,   hepatoP↑, 4,   neuroP↑, 3,   Obesity↓, 1,   OS↑, 12,   OS⇅, 1,   Pain↓, 3,   QoL↑, 5,   radioP↑, 6,   RenoP↑, 2,   Risk↓, 2,   Sleep↑, 1,   Strength↑, 2,   Symptoms∅, 1,   toxicity↓, 7,   toxicity↑, 1,   toxicity⇅, 1,   TumVol↓, 9,   TumVol∅, 1,   TumW↓, 4,   TumW∅, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 2,  
Total Targets: 751

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 3,   Stroke↓, 2,   β-HEX↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 16,   Catalase↑, 14,   GPx↑, 9,   GSH↑, 11,   GSR↑, 1,   GSTs↑, 6,   HO-1↓, 1,   HO-1↑, 6,   Keap1↓, 1,   lipid-P↓, 8,   MDA↓, 6,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 10,   ROS↓, 26,   ROS∅, 1,   SOD↑, 15,   SOD2↑, 1,   TAC↑, 2,   VitC↑, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 5,   BUN↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GLUT2↑, 1,   LDH↓, 1,   lipidLev↓, 1,   p‑PPARγ↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Casp3↓, 2,   iNOS↓, 2,   p‑JNK↓, 1,   necrosis↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HCAR2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   GSK‐3β↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   mTOR↓, 1,   PI3K↓, 1,   TRPM7↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   CLDN1↑, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,   ZO-1↑, 1,   β-Endo↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   NO↓, 4,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   GastroP↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   CRP↓, 1,   HCAR2↑, 1,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 3,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 16,   Inflam↑, 1,   NF-kB↓, 5,   PGE2↓, 1,   TNF-α↓, 7,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 2,   EndoR↑, 1,   monoA↑, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 8,   BioAv↝, 3,   BioEnh↑, 1,   Dose↑, 1,   eff↓, 1,   eff↑, 5,   Half-Life↝, 3,   P450↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 3,   BG↓, 1,   BMD↑, 3,   CRP↓, 1,   GutMicro↑, 2,   IL6↓, 3,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 1,   AntiArt↑, 2,   AntiCan↑, 5,   antiD↓, 1,   AntiDiabetic↑, 4,   AntiP↑, 1,   antiPs↑, 1,   cardioP↑, 7,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↓, 2,   cognitive↑, 2,   hepatoP↑, 10,   memory↑, 3,   motorD↓, 1,   motorD↑, 1,   neuroP?, 1,   neuroP↑, 15,   Obesity↓, 3,   OS↑, 2,   Pain↓, 1,   RenoP↑, 3,   toxicity↓, 3,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1,   AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 3,   Sepsis↓, 1,  
Total Targets: 140

Scientific Paper Hit Count for: IL6, Interleukin-6
7 Curcumin
7 Quercetin
6 Celastrol
6 Resveratrol
5 Propolis -bee glue
4 Apigenin (mainly Parsley)
4 Luteolin
4 Lycopene
4 Sulforaphane (mainly Broccoli)
3 Ashwagandha(Withaferin A)
3 Melatonin
3 Berberine
3 Beta-Caryophyllene
3 Caffeic acid
3 Crocetin
3 Ellagic acid
3 EGCG (Epigallocatechin Gallate)
3 Hydrogen Gas
3 Piperlongumine
3 Rosmarinic acid
3 Silymarin (Milk Thistle) silibinin
3 Shikonin
3 Urolithin
2 Silver-NanoParticles
2 Artemisinin
2 Ascorbyl Palmitate
2 beta-glucans
2 Baicalein
2 Boron
2 Chemotherapy
2 Chlorogenic acid
2 Chrysin
2 Radiotherapy/Radiation
2 Emodin
2 Fisetin
2 Cisplatin
2 Paclitaxel/Taxol
2 Honokiol
2 Hyperoside
2 Inositol
2 lambertianic acid
2 Linalool
2 Magnetic Field Rotating
2 Magnetic Fields
2 Piperine
1 2-DeoxyGlucose
1 Auranofin
1 Astragalus
1 alpha Linolenic acid
1 Andrographis
1 Isovitexin
1 Atorvastatin
1 immunotherapy
1 Berbamine
1 borneol
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Butyrate
1 Carvacrol
1 Centella asiatica / Gotu kola → asiaticoside
1 Oxygen, Hyperbaric
1 Dandelion Root
1 Tetrahydroxystilbene glucoside
1 Eugenol
1 Exercise
1 Galloflavin
1 Gambogic Acid
1 Garcinol
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Geraniol
1 Ginkgetin
1 Gossypol/AT-101
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 capecitabine
1 Isoliquiritigenin
1 Ivermectin
1 doxorubicin
1 Licochalcone A
1 Licorice
1 5-fluorouracil
1 Naringin
1 Niclosamide (Niclocide)
1 Nimbolide
1 Oleuropein
1 probiotics
1 Bifidobacterium
1 Perilla
1 Rauwolfia serpentina/Indian Snakeroot
1 Docetaxel
1 Selenite (Sodium)
1 Thymoquinone
1 Turmerones
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:158  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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