2/16-OHE1 Cancer Research Results

2/16-OHE1, 2-OHE1/16α-OHE1 Ratio/2-Hydroxyestrone to 16α-Hydroxyestrone Ratio: Click to Expand ⟱
Source:
Type:

2-OHE1/16α-OHE1 Ratio - 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio

Abbreviation: 2/16-OHE1 ratio, 2-OHE1/16α-OHE1, EMR

Type: Estrogen metabolism biomarker / metabolite ratio

Function: Represents the relative metabolism of estrone through the 2-hydroxylation versus 16α-hydroxylation pathways. 2-Hydroxyestrone has relatively weak estrogenic activity, whereas 16α-hydroxyestrone has greater estrogenic and potentially genotoxic/proliferative activity.

Cancer: ↓ A lower 2-OHE1/16α-OHE1 ratio has historically been proposed to represent a less favorable estrogen-metabolism profile and potentially greater breast-cancer risk, while an increased ratio has been considered potentially favorable. However, prospective studies and systematic reviews have found inconsistent associations, and the ratio is not considered a validated predictor of breast-cancer risk.

Direction: ↑ Traditionally considered favorable, but clinical significance remains uncertain.
Scientific Papers found: Click to Expand⟱
8830- DIM,  Tam,    A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen
- Trial, BC, NA
Dose?, 2/16-OHE1↓, SHBG↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↓, 1,   SHBG↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: 2/16-OHE1, 2-OHE1/16α-OHE1 Ratio/2-Hydroxyestrone to 16α-Hydroxyestrone Ratio
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1669  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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