AKR1C3/17β-HSD5/PGF Synthase Cancer Research Results

AKR1C3/17β-HSD5/PGF Synthase, Aldo-Keto Reductase Family 1 Member C3: Click to Expand ⟱

Source:

Type:

AKR1C3 - Aldo-Keto Reductase Family 1 Member C3

Abbreviation: AKR1C3, 17β-HSD5, PGF Synthase

Type: Aldo-keto reductase / hydroxysteroid dehydrogenase / prostaglandin-metabolizing enzyme

Function: AKR1C3 is an NADPH-dependent oxidoreductase involved in steroid hormone and prostaglandin metabolism. It converts weak androgen precursors into more active androgens, can convert estrone to estradiol, and reduces prostaglandin D2 to 11β-PGF2α. Through these activities, AKR1C3 regulates hormone-receptor signaling, prostaglandin signaling, cellular proliferation, and metabolic adaptation.

Cancer: ↑ Frequently overexpressed in multiple cancers and associated with enhanced proliferation, invasion, metastasis, tumor recurrence, and resistance to anticancer therapy. In hormone-dependent cancers, increased AKR1C3 can enhance local androgen and estrogen production and thereby activate androgen- or estrogen-receptor signaling. AKR1C3 inhibition can suppress tumor progression and restore treatment sensitivity in experimental models.

Scientific Papers found: Click to Expand⟱

8724-

MeJa,

Rad,

Methyl jasmonate enhances the radiation sensitivity of esophageal carcinoma cells by inhibiting the 11-ketoprostaglandin reductase activity of AKR1C3

in-vitro,

ESCC,

KYSE170

AKR1C3/17β-HSD5/PGF Synthase↓, ROS↑, RadioS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AKR1C3/17β-HSD5/PGF Synthase↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

RadioS↑, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: AKR1C3/17β-HSD5/PGF Synthase, Aldo-Keto Reductase Family 1 Member C3

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells