WDR72 Cancer Research Results

WDR72, WD Repeat Domain 72: Click to Expand ⟱
Source:
Type:

WDR72 - WD Repeat Domain 72

Abbreviation: WDR72

Type: WD-repeat scaffold protein / protein-protein interaction regulator

Function: WDR72 is a WD40 repeat-containing scaffold protein that provides a platform for assembly of protein complexes and is involved in regulation of cellular processes including proliferation, differentiation, adhesion, migration, vesicular trafficking, and tissue-specific functions such as enamel maturation.

Cancer: ↑ WDR72 is overexpressed in several cancers and can promote tumor-cell proliferation, survival, migration, invasion, stemness, and metastasis. In esophageal squamous cell carcinoma, WDR72 activates PI3K/AKT/mTOR signaling and suppresses autophagy. In neuroblastoma, WDR72 promotes stemness in part by stabilizing CBX8 through interference with TRIM31-mediated degradation.

Favorable Direction in Cancer: ↓ WDR72 expression or activity is generally favorable in tumors where WDR72 functions as an oncogenic scaffold and promotes PI3K/AKT/mTOR signaling, suppression of autophagy, proliferation, or stemness.

Interpretation Note: WDR72 is not an enzyme, so changes should generally be recorded as expression or functional activity rather than catalytic inhibition.
Scientific Papers found: Click to Expand⟱
8371- LT,    Study on the regulatory mechanism of luteolin inhibiting WDR72 on the proliferation and metastasis of non small cell lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Nor, BEAS-2B
TumCP↓, TumCI↓, TumCMig↓, TumVol↓, p‑Akt↓, Apoptosis↓, EMT↓, Dose↝, Akt↓, WDR72↓, TumMeta↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

WDR72↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: WDR72, WD Repeat Domain 72
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1815  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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