ITGA6 Cancer Research Results

ITGA6, Integrin Subunit Alpha 6: Click to Expand ⟱
Source:
Type:

ITGA6 - Integrin Subunit Alpha 6

Abbreviation: ITGA6, CD49f, Integrin α6

Alternative Names: Alpha-6 Integrin, VLA-6 Alpha Subunit

Type: Cell-adhesion receptor subunit / laminin receptor / integrin family protein

Function: ITGA6 forms heterodimeric integrin receptors primarily with ITGB1 or ITGB4, generating α6β1 and α6β4 integrins. These receptors bind laminins in the extracellular matrix and regulate cell adhesion, migration, survival, differentiation, polarity, stemness, and intracellular signaling.

Cancer: ↑ ITGA6 is frequently overexpressed in cancer and is associated with tumor-cell proliferation, invasion, migration, metastasis, cancer stem-cell properties, angiogenesis, and resistance to therapy. High ITGA6 expression is also associated with poor prognosis in several tumor types.

Favorable Direction in Cancer: ↓ ITGA6 expression or signaling is generally favorable where α6-integrin promotes tumor growth, stemness, invasion, metastasis, or treatment resistance.
Scientific Papers found: Click to Expand⟱
8383- LT,    Luteolin inhibits DNA methyltransferase 1 and alpha 6-integrin gene expression to suppress proliferation and stemness in breast cancer cells from patients of West African ancestry
- in-vivo, BC, NA
DNMT1↓, ITGA6↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ITGA6↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT1↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ITGA6, Integrin Subunit Alpha 6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1817  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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