CES1 Cancer Research Results

CES1, hCE1, carboxylesterase 1: Click to Expand ⟱
Source:
Type:

Carboxylesterase 1 (CES1; hCE1) — Major hepatic serine hydrolase involved in the hydrolysis and metabolism of ester-containing xenobiotics, drugs, prodrugs, and endogenous lipids. CES1 can influence drug activation/inactivation and lipid metabolism. In hepatocellular carcinoma, CES1 has been implicated in a CES1–PPARα/γ–SCD signaling axis associated with tumor progression and chemoresistance; CES1 inhibition can impair mitochondrial function and increase sensitivity to cisplatin.

Typical modulation in Alzheimer’s disease: Insufficient evidence for a consistent disease-associated direction.

Typical modulation in cancer: ↑ in some cancers, particularly hepatocellular carcinoma, where elevated CES1 activity may support lipid metabolism, tumor survival, and chemoresistance. However, effects are cancer- and drug-dependent because CES1 can also activate or deactivate ester-containing therapeutics.
Scientific Papers found: Click to Expand⟱
8515- MAG,    Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanism
- in-vitro, Liver, HepG2
CES1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CES1↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CES1, hCE1, carboxylesterase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1846  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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