Cavin3 Cancer Research Results

Cavin3, PRKCDBP,HSRBC,caveolae-associated protein 3: Click to Expand ⟱
Source:
Type:

CAVIN3 (Caveolae-Associated Protein 3; PRKCDBP/SRBC) — Caveolae-associated signaling protein and protein kinase C delta (PRKCD/PKCδ)-binding protein involved in regulation of intracellular signaling, caveolar function, and cytoskeletal organization. Older literature may refer to CAVIN3 as PRKCDBP, SRBC, or HSRBC.

Typical modulation in cancer: Generally considered tumor-suppressive in several cancer contexts. Loss or reduced expression of CAVIN3/PRKCDBP has been reported in malignancy and may favor abnormal growth and survival signaling; therefore CAVIN3 ↑ is generally interpreted as potentially anticancer, although effects can be tissue- and pathway-dependent.

Typical modulation in Alzheimer’s disease: No well-established Alzheimer’s disease-associated direction. Its relevance is primarily through caveolar and intracellular signaling rather than a recognized core AD mechanism.

Recommended abbreviation: CAVIN3; aliases: PRKCDBP, SRBC, HSRBC.
Scientific Papers found: Click to Expand⟱
8534- Matr,    Matrine induces apoptosis and autophagy in human lung adenocarcinoma cells via upregulation of Cavin3 and suppression of PI3K/AKT pathway
- in-vitro, Lung, A549 - in-vitro, Nor, MRC-5
TumCP↓, selectivity↑, Apoptosis↑, BAX↑, Bcl-2↓, TumAuto?, LC3II↑, Beclin-1/ATG6↑, p62↓, Cavin3↓, p‑PI3K↓, p‑Akt↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

Cavin3↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto?, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑PI3K↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Cavin3, PRKCDBP,HSRBC,caveolae-associated protein 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1847  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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