NR1D2 Cancer Research Results

NR1D2, REV-ERBβ, Nuclear Receptor Subfamily 1 Group D Member 2: Click to Expand ⟱
Source:
Type:

NR1D2 (Nuclear Receptor Subfamily 1 Group D Member 2; REV-ERBβ) — Nuclear receptor and transcriptional repressor that is a core component of the circadian clock. NR1D2/REV-ERBβ participates in transcriptional feedback with CLOCK/BMAL1 and regulates circadian rhythm, lipid and carbohydrate metabolism, inflammatory signaling, and other metabolic gene programs. It is closely related to NR1D1/REV-ERBα.

Typical modulation in cancer: Context-dependent. REV-ERB receptors are frequently dysregulated in cancer and can influence proliferation, metabolism, survival, circadian control, and tumor-associated metabolic programs. Reduced REV-ERB expression has been reported in multiple cancers, although the biological effect varies by cancer type and experimental context.

Typical modulation in Alzheimer’s disease: Potential relevance through circadian rhythm, metabolism, inflammation, and sleep regulation, but NR1D2 is not presently a core established Alzheimer’s disease target and no universal direction should be assigned.
Scientific Papers found: Click to Expand⟱
8543- Matr,    Mechanism of matrine inhibiting retinoblastoma cell growth by downregulating NR1D2 to regulate phosphorylation of the PI3K/AKT signaling pathway
- in-vitro, RPE/RB, Y79
TumCMig↓, Apoptosis↑, NR1D2↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

NR1D2↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑PI3K↓, 1,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NR1D2, REV-ERBβ, Nuclear Receptor Subfamily 1 Group D Member 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1848  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page