RCC1 Cancer Research Results

RCC1, Regulator of Chromosome Condensation 1: Click to Expand ⟱
Source:
Type:

RCC1 (Regulator of Chromosome Condensation 1) — Guanine nucleotide exchange factor (GEF) for the small GTPase RAN. RCC1 is bound to chromatin and generates nuclear Ran-GTP, establishing the Ran-GTP gradient that regulates nucleocytoplasmic transport, nuclear-envelope dynamics, mitotic spindle assembly, chromosome condensation, and cell-cycle progression.

Typical modulation in cancer: ↑ RCC1 is frequently associated with increased proliferation, mitotic activity, tumor progression, and poorer prognosis in several cancers. Cancer cells can depend on the RCC1–RAN signaling axis for nuclear transport and mitosis, so RCC1 inhibition or downregulation is generally considered potentially anticancer, although effects remain tumor-context dependent.
Scientific Papers found: Click to Expand⟱
8640- MBZ,  GB,    Disruption of epidermal growth factor receptor signaling and cytoskeletal dynamics by mebendazole and gefitinib synergistically impairs paracrine cytokine signaling in non-small cell lung cancer and triple-negative breast cancer Cell lines
- in-vitro, Lung, A549 - in-vitro, BC, MDA-MB-231
Synergy↑, tumCV↓, EGFR↓, RCC1↓, MMP2↓, STAT4↓, IL6↓, IL1β↓, TNF-α↑, IFN-γ↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Kinase & Signal Transduction(tgid=6) ⓘ

EGFR↓, 1,   RCC1↓, 1,   STAT4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↓, 1,   IL1β↓, 1,   IL6↓, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   IL6↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: RCC1, Regulator of Chromosome Condensation 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1879  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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