CS Cancer Research Results

CS, Citrate Synthase: Click to Expand ⟱
Source:
Type:

CS (Citrate Synthase) — Mitochondrial matrix enzyme that catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate, representing the first committed step of the tricarboxylic acid (TCA) cycle. Citrate synthase is widely used as a marker of mitochondrial oxidative capacity and mitochondrial content.

Typical modulation in cancer: Context-dependent. Increased citrate synthase activity can support oxidative metabolism and TCA-cycle flux in tumors that rely on mitochondrial respiration, whereas reduced CS activity can indicate suppression of mitochondrial oxidative metabolism. Cancer cells differ substantially in their dependence on glycolysis versus oxidative phosphorylation.

Typical modulation in Alzheimer’s disease: Reduced citrate synthase activity may reflect impaired mitochondrial function and reduced oxidative metabolism, both of which are relevant to neurodegenerative disease.
Scientific Papers found: Click to Expand⟱
8681- MLT,    Melatonin changes energy metabolism and reduces oncogenic signaling in ovarian cancer cells
- in-vitro, Ovarian, SKOV3
HIF-1↓, G6PD↓, GAPDH↓, PDH↓, CS↓, PFK1↓, LDH↓, PDH↑, lactateProd↓, glut↓, CREB↓, JNK↓, NF-kB↓, p38↓, ERK↓, Akt↓, P70S6K↓, STAT↓, Warburg↓, GlutaM↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

CS↓, 1,   PDH↓, 1,   PDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

G6PD↓, 1,   GAPDH↓, 1,   glut↓, 1,   GlutaM↓, 1,   lactateProd↓, 1,   PFK1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   CREB↓, 1,   ERK↓, 1,   JNK↓, 1,   P70S6K↓, 1,   STAT↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

HIF-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↓, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CS, Citrate Synthase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1883  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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