RRM2 Cancer Research Results

RRM2, Ribonucleotide Reductase Regulatory Subunit M2: Click to Expand ⟱
Source:
Type:

RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) — Regulatory small subunit of ribonucleotide reductase, the enzyme responsible for conversion of ribonucleotides to deoxyribonucleotides (dNTPs). RRM2 is strongly cell-cycle regulated and is required for DNA synthesis, DNA replication, DNA repair, and maintenance of intracellular dNTP pools.

Typical modulation in cancer: ↑ RRM2 is frequently tumor-promoting and is associated with increased proliferation, DNA replication, invasion, treatment resistance, and poorer prognosis in many cancers. RRM2 overexpression can also contribute to resistance to nucleoside analog drugs such as gemcitabine by increasing competing intracellular dNTP pools. RRM2 inhibition or knockdown generally suppresses proliferation and can increase DNA damage and apoptosis.

Ferroptosis relevance: RRM2 can function as an endogenous ferroptosis suppressor in several cancer models. RRM2 supports glutathione-related antioxidant capacity and nucleotide metabolism; RRM2 inhibition or knockdown can increase lipid peroxidation and ferroptosis in susceptible tumor cells.
Scientific Papers found: Click to Expand⟱
8686- MLT,  CAP,    Non-thermal plasma-treated melatonin inhibits the biological activity of HCC cells by increasing intracellular ROS levels and reducing RRM2 expression
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
Synergy↑, TumCI↓, TumCMig↓, Apoptosis↑, TumCP↓, TumMeta↓, radioP↑, ROS↑, RRM2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

RRM2↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Synergy↑, 1,  

Functional Outcomes(tgid=23) ⓘ

radioP↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: RRM2, Ribonucleotide Reductase Regulatory Subunit M2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1884  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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