ANGPT2 Cancer Research Results

ANGPT2, Ang2, Angiopoietin-2: Click to Expand ⟱

Source:

Type:

<p><b><span class="wphighlight">ANGPT2</span> (Angiopoietin-2; Ang-2)</b> — Secreted vascular growth factor and ligand of the endothelial receptor tyrosine kinase TIE2/TEK. <span class="wphighlight">ANGPT2</span> is produced predominantly by activated endothelial cells and regulates vascular remodeling, endothelial activation, vessel permeability, angiogenesis, inflammation, and interactions between endothelial cells and pericytes.</p>

<p><b>Typical modulation in cancer:</b> Frequently ↑ and generally tumor-promoting. Elevated <span class="wphighlight">ANGPT2</span> destabilizes tumor blood vessels, reduces pericyte coverage, increases endothelial responsiveness to VEGF, and promotes angiogenesis, vascular permeability, invasion, metastatic dissemination, and tumor progression. High circulating or tumor-associated <span class="wphighlight">ANGPT2</span> has been associated with advanced disease and poorer prognosis in multiple cancers. However, effects remain context-dependent because <span class="wphighlight">ANGPT2</span> can promote vessel regression when VEGF support is absent.</p>

<p><b>Typical mechanistic relationship:</b> <span class="wphighlight">ANGPT2</span> ↑ → ANGPT1/TIE2 vascular-stabilizing signaling ↓ → endothelial destabilization ↑ → VEGF sensitivity ↑ → endothelial sprouting / angiogenesis ↑.</p>

Scientific Papers found: Click to Expand⟱

8750-

MeSA,

Methylseleninic acid restricts tumor growth in nude mice model of metastatic breast cancer probably via inhibiting angiopoietin-2

vitro+vivo,

BC,

MDA-MB-231

nude mice carrying MDA-MB-231

ANGPT2↓, VEGF↓, TumVol↓, TumW↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Migration(tgid=13) ⓘ

ANGPT2↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1, TumW↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: ANGPT2, Ang2, Angiopoietin-2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells