ITGA2 Cancer Research Results

ITGA2, Integrin Subunit Alpha 2; CD49B: Click to Expand ⟱
Source:
Type:

ITGA2 (Integrin Subunit Alpha 2; CD49B) — Cell-surface adhesion receptor subunit that heterodimerizes with ITGB1 to form integrin α2β1, a major receptor for collagen and related extracellular-matrix proteins. ITGA2 regulates cell-matrix adhesion, focal adhesion formation, migration, invasion, mechanotransduction, and extracellular-matrix signaling.

Typical modulation in cancer: Frequently ↑ and tumor-promoting in several cancers. Elevated ITGA2 can promote adhesion to collagen-rich extracellular matrix, migration, invasion, EMT, metastatic dissemination, and survival signaling. Increased ITGA2 has been associated with metastasis and recurrence in breast, lung, glioma, thyroid, pancreatic, and other cancers, although effects remain context-dependent.

Typical mechanistic relationship: Collagen → ITGA2/ITGB1 (α2β1 integrin) → focal adhesion / FAK-SRC signaling → migration and invasion ↑.
Scientific Papers found: Click to Expand⟱
8819- MCP,  PacT,    Pectasol‐C Modified Citrus Pectin targets Galectin‐3‐induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids
- in-vitro, Ovarian, SKOV3
Gal-3↓, ChemoSen↑, STAT3↓, Hif1a↓, Akt↓, TumCMig↓, TumCI↓, ITGA2↓, ITGA5↓, ITGA6↓, ITGB1↓, ITGB3↓, ITGB4↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

ITGA2↓, 1,   ITGA5↓, 1,   ITGA6↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   ITGB4↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Gal-3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ITGA2, Integrin Subunit Alpha 2; CD49B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1894  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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